SARDH (sarcosine dehydrogenase)

2014-01-01  

Identity

HGNC
LOCATION
9q34.2
LOCUSID
ALIAS
BPR-2,DMGDHL1,SAR,SARD,SDH
FUSION GENES

Other Information

Locus ID:

NCBI: 1757
MIM: 604455
HGNC: 10536
Ensembl: ENSG00000123453

Variants:

dbSNP: 1757
ClinVar: 1757
TCGA: ENSG00000123453
COSMIC: SARDH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123453ENST00000298628Q9UL10
ENSG00000123453ENST00000371867Q5SYU9
ENSG00000123453ENST00000371868Q5SYV2
ENSG00000123453ENST00000371872Q9UL12
ENSG00000123453ENST00000422262A0A0A0MT55
ENSG00000123453ENST00000427237Q5SYV1
ENSG00000123453ENST00000439388Q9UL12

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Glycine, serine and threonine metabolismKEGGko00260
Glycine, serine and threonine metabolismKEGGhsa00260
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Choline catabolismREACTOMER-HSA-6798163

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
306939812019Alteration of the tumor suppressor SARDH in sporadic colorectal cancer: A functional and transcriptome profiling-based study.5
315454502019DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma.4
306939812019Alteration of the tumor suppressor SARDH in sporadic colorectal cancer: A functional and transcriptome profiling-based study.5
315454502019DNA methylation of sarcosine dehydrogenase (SARDH) loci as a prognosticator for renal cell carcinoma.4
270018972016Analysis of polymorphisms of genes associated with folate-mediated one-carbon metabolism and neural tube defects in Chinese Han Population.3
270018972016Analysis of polymorphisms of genes associated with folate-mediated one-carbon metabolism and neural tube defects in Chinese Han Population.3
258371632015Expression of sarcosine metabolism-related proteins in invasive lobular carcinoma: comparison to invasive ductal carcinoma.5
258371632015Expression of sarcosine metabolism-related proteins in invasive lobular carcinoma: comparison to invasive ductal carcinoma.5
238246052013TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells.23
238246052013TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells.23
228253172012Mutations in the sarcosine dehydrogenase gene in patients with sarcosinemia.6
228253172012Mutations in the sarcosine dehydrogenase gene in patients with sarcosinemia.6
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
191611602009An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).35

Citation

Dessen P

SARDH (sarcosine dehydrogenase)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53785