ASGR1 (asialoglycoprotein receptor 1)

2014-02-01  

Identity

HGNC
ASGR1
LOCATION
17p13.1
LOCUSID
432
ALIAS
ASGPR,ASGPR1,CLEC4H1,HL-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 432
MIM: 108360
HGNC: 742
Ensembl: ENSG00000141505

Variants:

dbSNP: 432
ClinVar: 432
TCGA: ENSG00000141505
COSMIC: ASGR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141505ENST00000269299P07306
ENSG00000141505ENST00000269299Q6FGQ5
ENSG00000141505ENST00000380920J3QSZ2
ENSG00000141505ENST00000570576I3L1F8
ENSG00000141505ENST00000572879I3L129
ENSG00000141505ENST00000573083I3L2S9
ENSG00000141505ENST00000574330K7EPS5
ENSG00000141505ENST00000574388P07306
ENSG00000141505ENST00000619926P07306

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
195208072009Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes.57
254859122015The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.57
271925412016Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease.24
247635452014Detection of circulating tumor cells in hepatocellular carcinoma using antibodies against asialoglycoprotein receptor, carbamoyl phosphate synthetase 1 and pan-cytokeratin.18
239798402013Expression of asialoglycoprotein receptor 1 in human hepatocellular carcinoma.12
272074302016Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance.8
121676172002Phosphorylation-dependent interaction of the asialoglycoprotein receptor with molecular chaperones.7
123701802002The position of cysteine relative to the transmembrane domain is critical for palmitoylation of H1, the major subunit of the human asialoglycoprotein receptor.7
212070812011Asialoglycoprotein receptor interacts with the preS1 domain of hepatitis B virus in vivo and in vitro.6
226136672012NMR study of ligand release from asialoglycoprotein receptor under solution conditions in early endosomes.6

Citation

Dessen P

ASGR1 (asialoglycoprotein receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53789/asgr1-(asialoglycoprotein-receptor-1)