IL10RB (interleukin 10 receptor subunit beta)

2014-02-01  

Identity

HGNC
LOCATION
21q22.11
LOCUSID
ALIAS
CDW210B,CRF2-4,CRFB4,D21S58,D21S66,IL-10R2
FUSION GENES

Other Information

Locus ID:

NCBI: 3588
MIM: 123889
HGNC: 5965
Ensembl: ENSG00000243646

Variants:

dbSNP: 3588
ClinVar: 3588
TCGA: ENSG00000243646
COSMIC: IL10RB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000243646ENST00000290200Q08334
ENSG00000243646ENST00000422891F8WDX2
ENSG00000243646ENST00000451065H7C0Z5
ENSG00000243646ENST00000609556A0A1B0GU52
ENSG00000243646ENST00000637650A0A1B0GTI5

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-19, 20, 22, 24REACTOMER-HSA-8854691
Interleukin-10 signalingREACTOMER-HSA-6783783

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375037442024Clinical and cellular phenotypes resulting from a founder mutation in IL10RB.0
375037442024Clinical and cellular phenotypes resulting from a founder mutation in IL10RB.0
375110502023Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.0
375110502023Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.0
352053362022Association of Interleukin Genes IL10 and IL10RB with Parameters of Overweight in Military Students.0
358115292022Regulation of the Human IL-10RB Gene Expression by Sp8 and Sp9.1
352053362022Association of Interleukin Genes IL10 and IL10RB with Parameters of Overweight in Military Students.0
358115292022Regulation of the Human IL-10RB Gene Expression by Sp8 and Sp9.1
335951402021IL-10 receptor expression on lymphocytes and monocytes in children with food allergy.1
339496682021Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19.22
335951402021IL-10 receptor expression on lymphocytes and monocytes in children with food allergy.1
339496682021Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19.22
326117652020Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10 receptor 2 and functional cross-talk with the IL-6 receptor gp130.9
332606952020Susceptibility to Heart Defects in Down Syndrome Is Associated with Single Nucleotide Polymorphisms in HAS 21 Interferon Receptor Cluster and VEGFA Genes.8
326117652020Synthetic interleukin 22 (IL-22) signaling reveals biological activity of homodimeric IL-10 receptor 2 and functional cross-talk with the IL-6 receptor gp130.9

Citation

Dessen P

IL10RB (interleukin 10 receptor subunit beta)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53793/il10rb-(interleukin-10-receptor-subunit-beta)