Identity
HGNC
LOCATION
11p15.1
LOCUSID
ALIAS
BIR,HHF2,IKATP,KIR6.2,MODY13,PHHI,PNDM2,TNDM3
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3767
MIM: 600937
HGNC: 6257
Ensembl: ENSG00000187486
Variants:
dbSNP: 3767
ClinVar: 3767
TCGA: ENSG00000187486
COSMIC: KCNJ11
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10390 | sulfonamides, urea derivatives | Chemical | ClinicalAnnotation, VariantAnnotation, VipGene | ambiguous | PK | PD | 15448106, 15838686, 16595597, 16731836, 11318841, 16595597, 22385882, 24442125, 25115353 |
| PA10892 | gliclazide | Chemical | ClinicalAnnotation | associated | PK | PD | 11318841, 16595597, 22385882, 24442125, 25115353 |
| PA150527845 | Persistent Hyperinsulinemia Hypoglycemia of Infancy | Disease | VipGene | associated | 12199344 | ||
| PA152530787 | Diabetes, Permanent Neonatal (PNDM) | Disease | VipGene | associated | 16087682, 15580558 | ||
| PA164744895 | gliquidone | Chemical | ClinicalAnnotation | associated | PK | PD | 11318841, 16595597, 22385882, 24442125, 25115353 |
| PA166154256 | rs5219 | Variant | VipGene | associated | 11872696, 12196481, 12351459, 12475776, 12540637, 12540638, 12605956, 15111507, 15565284, 15579791, 15842514, 15855351, 16595597, 8897013, 9568693, 11318841 | ||
| PA443635 | Cardiovascular Diseases | Disease | VipGene | associated | 16455067, 16782803, 14871556 | ||
| PA443886 | Diabetes Mellitus | Disease | ClinicalAnnotation, VipGene | associated | PK | PD | 12540637, 12540638, 15111507, 15579791, 15784703, 15797964, 15842514, 16885550, 9032109, 11318841, 16595597, 22385882, 24442125, 25115353 |
| PA443890 | Diabetes Mellitus, Type 2 | Disease | ClinicalAnnotation | associated | PD | 11318841, 16595597, 20054294, 22264780, 22385882, 24442125, 25115353 | |
| PA449285 | diazoxide | Chemical | VipGene | associated | 15807877, 16885550, 12199344 | ||
| PA449761 | glimepiride | Chemical | ClinicalAnnotation | associated | PK | PD | 11318841, 16595597, 22385882, 24442125, 25115353 |
| PA449762 | glipizide | Chemical | ClinicalAnnotation | associated | PK | PD | 11318841, 16595597, 22385882, 24442125, 25115353 |
| PA449782 | glibenclamide | Chemical | ClinicalAnnotation | associated | PK | PD | 11318841, 16595597, 22385882, 24442125, 25115353 |
| PA450395 | metformin | Chemical | ClinicalAnnotation | associated | PD | 16595597 | |
| PA451234 | repaglinide | Chemical | ClinicalAnnotation | associated | PD | 20054294 | |
| PA451578 | tacrolimus | Chemical | ClinicalAnnotation | associated | PD | 22264780 | |
| PA451718 | tolbutamide | Chemical | VariantAnnotation | not associated | PK | 8897013 | |
| PA452249 | antiarrhythmics, class i and iii | Chemical | VipGene | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38411150 | 2024 | An analysis of the relationship between ABCC8 and KCNJ11 gene polymorphisms and diabetic retinopathy in Turkish population. | 0 |
| 38675722 | 2024 | Molecular Dynamics Simulation of Kir6.2 Variants Reveals Potential Association with Diabetes Mellitus. | 0 |
| 38411150 | 2024 | An analysis of the relationship between ABCC8 and KCNJ11 gene polymorphisms and diabetic retinopathy in Turkish population. | 0 |
| 38675722 | 2024 | Molecular Dynamics Simulation of Kir6.2 Variants Reveals Potential Association with Diabetes Mellitus. | 0 |
| 37052755 | 2023 | Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study. | 5 |
| 37175633 | 2023 | Protection against Ischemic Heart Disease: A Joint Role for eNOS and the K(ATP) Channel. | 3 |
| 37341850 | 2023 | Sex differences of the shared genetic landscapes between type 2 diabetes and peripheral artery disease in East Asians and Europeans. | 0 |
| 37052755 | 2023 | Repurposing antidiabetic drugs for rheumatoid arthritis: results from a two-sample Mendelian randomization study. | 5 |
| 37175633 | 2023 | Protection against Ischemic Heart Disease: A Joint Role for eNOS and the K(ATP) Channel. | 3 |
| 37341850 | 2023 | Sex differences of the shared genetic landscapes between type 2 diabetes and peripheral artery disease in East Asians and Europeans. | 0 |
| 35305868 | 2022 | Association between KCNJ11 E23K polymorphism and the risk of type 2 diabetes mellitus: A global meta-analysis. | 1 |
| 35822653 | 2022 | Clinical presentation and long-term outcome of patients with KCNJ11/ABCC8 variants: Neonatal diabetes or MODY in the DPV registry from Germany and Austria. | 5 |
| 35893051 | 2022 | KCNJ11 and KCNQ1 Gene Polymorphisms and Placental Expression in Women with Gestational Diabetes Mellitus. | 4 |
| 35996512 | 2022 | The E23K Polymorphism of KCNJ11 and Diabetic Retinopathy in Northern Iran. | 0 |
| 36401380 | 2022 | Association of KCNJ11 and ABCC8 single-nucleotide polymorphisms with type 2 diabetes mellitus in a Kinh Vietnamese population. | 3 |
Citation
Dessen P
KCNJ11 (potassium inwardly rectifying channel subfamily J member 11)
Atlas Genet Cytogenet Oncol Haematol. 2014-02-01
Online version: http://atlasgeneticsoncology.org/gene/53794/kcnj11-(potassium-inwardly-rectifying-channel-subfamily-j-member-11)
