UNC5D (unc-5 netrin receptor D)

2014-02-01  

Identity

HGNC
UNC5D
LOCATION
8p12
LOCUSID
137970
ALIAS
PRO34692,Unc5h4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 137970
MIM: 616466
HGNC: 18634
Ensembl: ENSG00000156687

Variants:

dbSNP: 137970
ClinVar: 137970
TCGA: ENSG00000156687
COSMIC: UNC5D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156687ENST00000287272H7BXJ2
ENSG00000156687ENST00000404895Q6UXZ4
ENSG00000156687ENST00000416672C9J2B6
ENSG00000156687ENST00000420357C9J1I0
ENSG00000156687ENST00000449677E9PDS8
ENSG00000156687ENST00000453357Q6UXZ4

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Netrin mediated repulsion signalsREACTOMER-HSA-418886

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
382358712024The expression of UNC5D is abnormal in the early stage of colorectal tumors associated with its proliferation and migration.0
382358712024The expression of UNC5D is abnormal in the early stage of colorectal tumors associated with its proliferation and migration.0
330786312020Hypermethylated promoters of genes UNC5D and KCNA1 as potential novel diagnostic biomarkers in colorectal cancer.11
330786312020Hypermethylated promoters of genes UNC5D and KCNA1 as potential novel diagnostic biomarkers in colorectal cancer.11
306326692019UNC5D, suppressed by promoter hypermethylation, inhibits cell metastasis by activating death-associated protein kinase 1 in prostate cancer.8
306326692019UNC5D, suppressed by promoter hypermethylation, inhibits cell metastasis by activating death-associated protein kinase 1 in prostate cancer.8
287541762017Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment.8
287541762017Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment.8
245190682014Overexpression of the dependence receptor UNC5H4 inhibits cell migration and invasion, and triggers apoptosis in neuroblastoma cell.2
246916572014Unc5D regulates p53-dependent apoptosis in neuroblastoma cells.9
245190682014Overexpression of the dependence receptor UNC5H4 inhibits cell migration and invasion, and triggers apoptosis in neuroblastoma cell.2
246916572014Unc5D regulates p53-dependent apoptosis in neuroblastoma cells.9
235891792013The tumor-suppressive function of UNC5D and its repressed expression in renal cell carcinoma.9
237781382013Dependence receptor UNC5D mediates nerve growth factor depletion-induced neuroblastoma regression.23
235891792013The tumor-suppressive function of UNC5D and its repressed expression in renal cell carcinoma.9

Citation

Dessen P

UNC5D (unc-5 netrin receptor D)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53800/unc5d-(unc-5-netrin-receptor-d)