WDR62 (WD repeat domain 62)

2014-02-01 Affiliation

Identity

HGNC

WDR62

LOCATION

19q13.12

LOCUSID

284403

ALIAS

C19orf14,MCPH2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 284403
MIM: 613583
HGNC: 24502
Ensembl: ENSG00000075702

Variants:

dbSNP: 284403
ClinVar: 284403
TCGA: ENSG00000075702
COSMIC: WDR62

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000075702	ENST00000270301	O43379
ENSG00000075702	ENST00000401500	O43379
ENSG00000075702	ENST00000427823	H7C3R4
ENSG00000075702	ENST00000587391	O43379
ENSG00000075702	ENST00000644764	A0A2R8YD43

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
38926176	2024	Molecular genetics, neuroimaging outcomes, and structural analyses of novel and recurrent variants of WDR62 gene in two consanguineous Pakistani families with autosomal recessive primary microcephaly.	0
38926176	2024	Molecular genetics, neuroimaging outcomes, and structural analyses of novel and recurrent variants of WDR62 gene in two consanguineous Pakistani families with autosomal recessive primary microcephaly.	0
35726608	2022	Neurological outcome in WDR62 primary microcephaly.	3
35758246	2022	WD repeat domain 62 (WDR62) promotes resistance of colorectal cancer to oxaliplatin through modulating mitogen-activated protein kinase (MAPK) signaling.	3
35808830	2022	WDR62 variants contribute to congenital heart disease by inhibiting cardiomyocyte proliferation.	4
35726608	2022	Neurological outcome in WDR62 primary microcephaly.	3
35758246	2022	WD repeat domain 62 (WDR62) promotes resistance of colorectal cancer to oxaliplatin through modulating mitogen-activated protein kinase (MAPK) signaling.	3
35808830	2022	WDR62 variants contribute to congenital heart disease by inhibiting cardiomyocyte proliferation.	4
33921653	2021	Further Delineation of Phenotype and Genotype of Primary Microcephaly Syndrome with Cortical Malformations Associated with Mutations in the WDR62 Gene.	3
34137788	2021	WDR62 localizes katanin at spindle poles to ensure synchronous chromosome segregation.	7
34137789	2021	WDR62 regulates spindle dynamics as an adaptor protein between TPX2/Aurora A and katanin.	13
34306258	2021	Systematic Analysis of the Oncogenic Role of WDR62 in Human Tumors.	5
34326322	2021	An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer.	14
33921653	2021	Further Delineation of Phenotype and Genotype of Primary Microcephaly Syndrome with Cortical Malformations Associated with Mutations in the WDR62 Gene.	3
34137788	2021	WDR62 localizes katanin at spindle poles to ensure synchronous chromosome segregation.	7

Citation

Dessen P

WDR62 (WD repeat domain 62)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53801/wdr62-(wd-repeat-domain-62)