EZHIP (EZH inhibitory protein)

2014-03-01  

Identity

HGNC
EZHIP
LOCATION
Xp11.22
LOCUSID
340602
ALIAS
CATACOMB,CXorf67,KIP75

Other Information

Locus ID:

NCBI: 340602
MIM: 301036
HGNC: 33738
Ensembl: ENSG00000187690

Variants:

dbSNP: 340602
ClinVar: 340602
TCGA: ENSG00000187690
COSMIC: EZHIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187690ENST00000342995Q86X51
ENSG00000187690ENST00000342995A0A515VFR0

References

Pubmed IDYearTitleCitations
355116352022[The value of CXorf67 and H3K27me3 for diagnosing germ cell tumors in central nervous system].0
355116352022[The value of CXorf67 and H3K27me3 for diagnosing germ cell tumors in central nervous system].0
331309282021EZH2 inhibitory protein (EZHIP/Cxorf67) expression correlates strongly with H3K27me3 loss in posterior fossa ependymomas and is mutually exclusive with H3K27M mutations.13
331309282021EZH2 inhibitory protein (EZHIP/Cxorf67) expression correlates strongly with H3K27me3 loss in posterior fossa ependymomas and is mutually exclusive with H3K27M mutations.13
321937872020Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation.55
331534942020EZHIP is a specific diagnostic biomarker for posterior fossa ependymomas, group PFA and diffuse midline gliomas H3-WT with EZHIP overexpression.18
331865202020Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors.14
321937872020Histone H3 wild-type DIPG/DMG overexpressing EZHIP extend the spectrum diffuse midline gliomas with PRC2 inhibition beyond H3-K27M mutation.55
331534942020EZHIP is a specific diagnostic biomarker for posterior fossa ependymomas, group PFA and diffuse midline gliomas H3-WT with EZHIP overexpression.18
331865202020Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors.14
309238262019EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.68
310861752019PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism.83
312819012019CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.56
314516852019EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.47
309238262019EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.68

Citation

Dessen P

EZHIP (EZH inhibitory protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53814/ezhip-(ezh-inhibitory-protein)