FFAR4 (free fatty acid receptor 4)

2014-03-01  

Identity

HGNC
LOCATION
10q23.33
LOCUSID
ALIAS
BMIQ10,GPR120,GPR129,GT01,O3FAR1,PGR4

Other Information

Locus ID:

NCBI: 338557
MIM: 609044
HGNC: 19061
Ensembl: ENSG00000186188

Variants:

dbSNP: 338557
ClinVar: 338557
TCGA: ENSG00000186188
COSMIC: FFAR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186188ENST00000371481Q5NUL3
ENSG00000186188ENST00000371483Q5NUL3
ENSG00000186188ENST00000604414S4R3L2

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)REACTOMER-HSA-381771
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Free fatty acid receptorsREACTOMER-HSA-444209

References

Pubmed IDYearTitleCitations
382431882024FFAR4 activation inhibits lung adenocarcinoma via blocking respiratory chain complex assembly associated mitochondrial metabolism.0
382431882024FFAR4 activation inhibits lung adenocarcinoma via blocking respiratory chain complex assembly associated mitochondrial metabolism.0
364022502023Immune regulation of poly unsaturated fatty acids and free fatty acid receptor 4.7
372018772023Free-Fatty Acid Receptor-4 (FFA4/GPR120) differentially regulates migration, invasion, proliferation and tumor growth of papillary renal cell carcinoma cells.3
375425252023GPR120/FFAR4: A Potential New Therapeutic Target for Inflammatory Bowel Disease.0
378422922023Predictive value of first-trimester GPR120 levels in gestational diabetes mellitus.0
364022502023Immune regulation of poly unsaturated fatty acids and free fatty acid receptor 4.7
372018772023Free-Fatty Acid Receptor-4 (FFA4/GPR120) differentially regulates migration, invasion, proliferation and tumor growth of papillary renal cell carcinoma cells.3
375425252023GPR120/FFAR4: A Potential New Therapeutic Target for Inflammatory Bowel Disease.0
378422922023Predictive value of first-trimester GPR120 levels in gestational diabetes mellitus.0
350133892022GPR120 prevents colorectal adenocarcinoma progression by sustaining the mucosal barrier integrity.11
355886282022Free fatty acid receptor 4 deletion attenuates colitis by modulating Treg Cells via ZBED6-IL33 pathway.11
357039492022Reduced Free Fatty Acid Receptor 4 Gene Expression is Associated With Extreme Obesity and Insulin Resistance in Children.0
357173052022GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma.1
363090792022Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells.5

Citation

Dessen P

FFAR4 (free fatty acid receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53816/