RPS15A (ribosomal protein S15a)

2014-03-01  

Identity

HGNC
LOCATION
16p12.3
LOCUSID
ALIAS
DBA20,S15a
FUSION GENES

Other Information

Locus ID:

NCBI: 6210
MIM: 603674
HGNC: 10389
Ensembl: ENSG00000134419

Variants:

dbSNP: 6210
ClinVar: 6210
TCGA: ENSG00000134419
COSMIC: RPS15A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134419ENST00000322989P62244
ENSG00000134419ENST00000322989B2R4W8
ENSG00000134419ENST00000562935H3BT37
ENSG00000134419ENST00000563390P62244
ENSG00000134419ENST00000563390B2R4W8
ENSG00000134419ENST00000563579H3BVC7
ENSG00000134419ENST00000565420P62244
ENSG00000134419ENST00000565420B2R4W8
ENSG00000134419ENST00000569083I3L3P7
ENSG00000134419ENST00000569365H3BV27
ENSG00000134419ENST00000572008P62244
ENSG00000134419ENST00000572008B2R4W8
ENSG00000134419ENST00000574723I3L303
ENSG00000134419ENST00000576008I3L246
ENSG00000134419ENST00000576436I3L246

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
RibosomeKEGGko03010
RibosomeKEGGhsa03010
Ribosome, eukaryotesKEGGhsa_M00177
Ribosome, eukaryotesKEGGM00177
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
Formation of a pool of free 40S subunitsREACTOMER-HSA-72689
Formation of the ternary complex, and subsequently, the 43S complexREACTOMER-HSA-72695
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SREACTOMER-HSA-72662
Translation initiation complex formationREACTOMER-HSA-72649
Ribosomal scanning and start codon recognitionREACTOMER-HSA-72702
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
L13a-mediated translational silencing of Ceruloplasmin expressionREACTOMER-HSA-156827
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Eukaryotic Translation ElongationREACTOMER-HSA-156842
Peptide chain elongationREACTOMER-HSA-156902
Eukaryotic Translation TerminationREACTOMER-HSA-72764
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral mRNA TranslationREACTOMER-HSA-192823
Gene ExpressionREACTOMER-HSA-74160
Nonsense-Mediated Decay (NMD)REACTOMER-HSA-927802
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)REACTOMER-HSA-975957
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)REACTOMER-HSA-975956
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
Selenocysteine synthesisREACTOMER-HSA-2408557
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
370161672023FOXN3 inhibits the progression of ovarian cancer through negatively regulating the expression of RPS15A.0
370697462023MicroRNA-147b induces neuroendocrine differentiation of prostate cancer cells by targeting ribosomal protein RPS15A.1
370161672023FOXN3 inhibits the progression of ovarian cancer through negatively regulating the expression of RPS15A.0
370697462023MicroRNA-147b induces neuroendocrine differentiation of prostate cancer cells by targeting ribosomal protein RPS15A.1
341566952021Ribosomal protein RPS15A augments proliferation of colorectal cancer RKO cells via regulation of BIRC3, p38 MAPK and Chk1.1
341566952021Ribosomal protein RPS15A augments proliferation of colorectal cancer RKO cells via regulation of BIRC3, p38 MAPK and Chk1.1
315354102020Ribosomal protein small subunit 15A (RPS15A) inhibits the apoptosis of breast cancer MDA-MB-231 cells via upregulating phosphorylated ERK1/2, Bad, and Chk1.2
316658072020MicroRNA-147b suppresses the proliferation and invasion of non-small-cell lung cancer cells through downregulation of Wnt/β-catenin signalling via targeting of RPS15A.4
315354102020Ribosomal protein small subunit 15A (RPS15A) inhibits the apoptosis of breast cancer MDA-MB-231 cells via upregulating phosphorylated ERK1/2, Bad, and Chk1.2
316658072020MicroRNA-147b suppresses the proliferation and invasion of non-small-cell lung cancer cells through downregulation of Wnt/β-catenin signalling via targeting of RPS15A.4
305691432019Knockdown of ribosomal protein S15A inhibits human kidney cancer cell growth in vitro and in vivo.3
306612912019RPS15A promotes gastric cancer progression via activation of the Akt/IKK-β/NF-κB signalling pathway.23
313031292019Downregulation of RPS15A by miR-29a-3p attenuates cell proliferation in colorectal carcinoma.10
305691432019Knockdown of ribosomal protein S15A inhibits human kidney cancer cell growth in vitro and in vivo.3
306612912019RPS15A promotes gastric cancer progression via activation of the Akt/IKK-β/NF-κB signalling pathway.23

Citation

Dessen P

RPS15A (ribosomal protein S15a)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53827/rps15a-(ribosomal-protein-s15a)