USP12 (ubiquitin specific peptidase 12)

2014-03-01  

Identity

HGNC
USP12
LOCATION
13q12.13
LOCUSID
219333
ALIAS
UBH1,USP12L1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 219333
MIM: 603091
HGNC: 20485
Ensembl: ENSG00000152484

Variants:

dbSNP: 219333
ClinVar: 219333
TCGA: ENSG00000152484
COSMIC: USP12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152484ENST00000282344O75317
ENSG00000152484ENST00000612674A0A087WWP2
ENSG00000152484ENST00000620323A0A087WUU2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381139772024USP12 regulates ER stress-associated osteogenesis in human periodontal ligament cells under tension stress.0
381139772024USP12 regulates ER stress-associated osteogenesis in human periodontal ligament cells under tension stress.0
373416112023USP12 promotes nonsmall cell lung cancer progression through deubiquitinating and stabilizing RRM2.2
373416112023USP12 promotes nonsmall cell lung cancer progression through deubiquitinating and stabilizing RRM2.2
358981712022USP12 positively regulates M-MDSC function to inhibit antitumour immunity through deubiquitinating and stabilizing p65.7
358981712022USP12 positively regulates M-MDSC function to inhibit antitumour immunity through deubiquitinating and stabilizing p65.7
343810282021USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.16
343810282021USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.16
331740332020Downregulation of USP12 inhibits tumor growth via the p38/MAPK pathway in hepatocellular carcinoma.5
331740332020Downregulation of USP12 inhibits tumor growth via the p38/MAPK pathway in hepatocellular carcinoma.5
304669592019WDR20 regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus.5
304669592019WDR20 regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus.5
297551292018Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12.24
302669092018Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease.30
297551292018Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12.24

Citation

Dessen P

USP12 (ubiquitin specific peptidase 12)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53833/usp12-(ubiquitin-specific-peptidase-12)