RAMP1 (receptor activity modifying protein 1)

2014-03-01  

Identity

HGNC
LOCATION
2q37.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 10267
MIM: 605153
HGNC: 9843
Ensembl: ENSG00000132329

Variants:

dbSNP: 10267
ClinVar: 10267
TCGA: ENSG00000132329
COSMIC: RAMP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132329ENST00000254661O60894
ENSG00000132329ENST00000403885E9PC20
ENSG00000132329ENST00000404910E9PC20
ENSG00000132329ENST00000409726E9PC20

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000

Pathways

PathwaySourceExternal ID
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Calcitonin-like ligand receptorsREACTOMER-HSA-419812
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

References

Pubmed IDYearTitleCitations
350076602022Peptide ligand interaction with maltose-binding protein tagged to the calcitonin gene-related peptide receptor: The inhibitory role of receptor N-glycosylation.1
350076602022Peptide ligand interaction with maltose-binding protein tagged to the calcitonin gene-related peptide receptor: The inhibitory role of receptor N-glycosylation.1
336028642021Structure and dynamics of the CGRP receptor in apo and peptide-bound forms.41
336028642021Structure and dynamics of the CGRP receptor in apo and peptide-bound forms.41
292977362019Increased receptor activity-modifying protein 1 in the nervous system is sufficient to protect against autonomic dysregulation and hypertension.9
311504172019Development of chimeric and bifunctional antagonists for CLR/RAMP receptors.9
292977362019Increased receptor activity-modifying protein 1 in the nervous system is sufficient to protect against autonomic dysregulation and hypertension.9
311504172019Development of chimeric and bifunctional antagonists for CLR/RAMP receptors.9
302094002018Cryo-EM structure of the active, G(s)-protein complexed, human CGRP receptor.112
302094002018Cryo-EM structure of the active, G(s)-protein complexed, human CGRP receptor.112
281814962017Haplotype-based, case-control study of the receptor (calcitonin) activity-modifying protein (RAMP) 1 gene in essential hypertension.0
286918012017Relative Antagonism of Mutants of the CGRP Receptor Extracellular Loop 2 Domain (ECL2) Using a Truncated Competitive Antagonist (CGRP(8-37)): Evidence for the Dual Involvement of ECL2 in the Two-Domain Binding Model.1
281814962017Haplotype-based, case-control study of the receptor (calcitonin) activity-modifying protein (RAMP) 1 gene in essential hypertension.0
286918012017Relative Antagonism of Mutants of the CGRP Receptor Extracellular Loop 2 Domain (ECL2) Using a Truncated Competitive Antagonist (CGRP(8-37)): Evidence for the Dual Involvement of ECL2 in the Two-Domain Binding Model.1
258819902015Association of RAMP1 rs7590387 with the risk of migraine transformation into medication overuse headache.9

Citation

Dessen P

RAMP1 (receptor activity modifying protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53840/ramp1-(receptor-activity-modifying-protein-1)