GPR17 (G protein-coupled receptor 17)

2014-03-01  

Identity

HGNC
LOCATION
2q14.3
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 2840
MIM: 603071
HGNC: 4471
Ensembl: ENSG00000144230

Variants:

dbSNP: 2840
ClinVar: 2840
TCGA: ENSG00000144230
COSMIC: GPR17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144230ENST00000272644Q13304
ENSG00000144230ENST00000393018Q13304
ENSG00000144230ENST00000423019C9JWY5
ENSG00000144230ENST00000544369Q13304

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Eicosanoid ligand-binding receptorsREACTOMER-HSA-391903
Leukotriene receptorsREACTOMER-HSA-391906
Nucleotide-like (purinergic) receptorsREACTOMER-HSA-418038
P2Y receptorsREACTOMER-HSA-417957
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
367912782023Structural analysis of human G-protein-coupled receptor 17 ligand binding sites.0
367912782023Structural analysis of human G-protein-coupled receptor 17 ligand binding sites.0
331406892022Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication.7
350168812022GPR17 signaling activation by CHBC agonist induced cell death via modulation of MAPK pathway in glioblastoma.4
351634372022Insulin-like Growth Factor 1 Promotes Cell Proliferation by Downregulation of G-Protein-Coupled Receptor 17 Expression via PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells.0
331406892022Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication.7
350168812022GPR17 signaling activation by CHBC agonist induced cell death via modulation of MAPK pathway in glioblastoma.4
351634372022Insulin-like Growth Factor 1 Promotes Cell Proliferation by Downregulation of G-Protein-Coupled Receptor 17 Expression via PI3K/Akt/FoxO1 Signaling in SK-N-SH Cells.0
333098822021Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis.39
339254692021The Distribution of GPR17-Expressing Cells Correlates with White Matter Inflammation Status in Brain Tissues of Multiple Sclerosis Patients.10
341201402021G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production.10
341440382021Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles.2
333098822021Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis.39
339254692021The Distribution of GPR17-Expressing Cells Correlates with White Matter Inflammation Status in Brain Tissues of Multiple Sclerosis Patients.10
341201402021G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production.10

Citation

Dessen P

GPR17 (G protein-coupled receptor 17)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53846/gpr17-(g-protein-coupled-receptor-17)