SCIN (scinderin)

Identity

HGNC

SCIN

LOCATION

7p21.3

LOCUSID

85477

ALIAS

-

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 85477
MIM: 613416
HGNC: 21695
Ensembl: ENSG00000006747

Variants:

dbSNP: 85477
ClinVar: 85477
TCGA: ENSG00000006747
COSMIC: SCIN

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000006747	ENST00000297029	Q9Y6U3
ENSG00000006747	ENST00000341757	Q9Y6U3
ENSG00000006747	ENST00000417018	C9JGB6
ENSG00000006747	ENST00000436854	F8WBX5
ENSG00000006747	ENST00000518849	E5RHN8
ENSG00000006747	ENST00000519209	Q9Y6U3
ENSG00000006747	ENST00000523729	E5RHX6

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Expression (GTEx)

0

5

10

15

20

25

30

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Fc gamma R-mediated phagocytosis	KEGG	ko04666
Fc gamma R-mediated phagocytosis	KEGG	hsa04666
Regulation of actin cytoskeleton	KEGG	ko04810
Regulation of actin cytoskeleton	KEGG	hsa04810
Viral carcinogenesis	KEGG	hsa05203
Viral carcinogenesis	KEGG	ko05203

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
24212916	2014	Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest.	24
25303873	2015	Lentivirus-mediated silencing of SCIN inhibits proliferation of human lung carcinoma cells.	15
25303873	2015	Lentivirus-mediated silencing of SCIN inhibits proliferation of human lung carcinoma cells.	15
27033455	2016	Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients.	30
27033455	2016	Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients.	30
27347659	2016	A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants.	7
27347659	2016	A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants.	7
28213129	2017	Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip.	3
28213129	2017	Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip.	3
29457658	2018	Decreased SCIN expression, associated with promoter methylation, is a valuable predictor for prognosis in acute myeloid leukemia.	10

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Citation

Dessen P

SCIN (scinderin)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53852