SCIN (scinderin)

2014-03-01  

Identity

HGNC
SCIN
LOCATION
7p21.3
LOCUSID
85477
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 85477
MIM: 613416
HGNC: 21695
Ensembl: ENSG00000006747

Variants:

dbSNP: 85477
ClinVar: 85477
TCGA: ENSG00000006747
COSMIC: SCIN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000006747ENST00000297029Q9Y6U3
ENSG00000006747ENST00000341757Q9Y6U3
ENSG00000006747ENST00000417018C9JGB6
ENSG00000006747ENST00000436854F8WBX5
ENSG00000006747ENST00000518849E5RHN8
ENSG00000006747ENST00000519209Q9Y6U3
ENSG00000006747ENST00000523729E5RHX6

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
361486822022The AHR target gene scinderin activates the WNT pathway by facilitating the nuclear translocation of β-catenin.2
361486822022The AHR target gene scinderin activates the WNT pathway by facilitating the nuclear translocation of β-catenin.2
312049122019[Clinical Study of SCIN Expression and Dromoter Methylation in Patients with Chronic Myeloid Leukemia].1
312049122019[Clinical Study of SCIN Expression and Dromoter Methylation in Patients with Chronic Myeloid Leukemia].1
294576582018Decreased SCIN expression, associated with promoter methylation, is a valuable predictor for prognosis in acute myeloid leukemia.10
294576582018Decreased SCIN expression, associated with promoter methylation, is a valuable predictor for prognosis in acute myeloid leukemia.10
282131292017Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip.3
282131292017Cyclic compressive stress-induced scinderin regulates progress of developmental dysplasia of the hip.3
270334552016Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients.30
273476592016A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants.7
270334552016Scinderin promotes the invasion and metastasis of gastric cancer cells and predicts the outcome of patients.30
273476592016A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants.7
253038732015Lentivirus-mediated silencing of SCIN inhibits proliferation of human lung carcinoma cells.15
253038732015Lentivirus-mediated silencing of SCIN inhibits proliferation of human lung carcinoma cells.15
242129162014Suppression of SCIN inhibits human prostate cancer cell proliferation and induces G0/G1 phase arrest.24

Citation

Dessen P

SCIN (scinderin)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53852/favicon/welcome