Identity
HGNC
LOCATION
4q13.3
LOCUSID
ALIAS
GCP-1,GCP1,IL8,LECT,LUCT,LYNAP,MDNCF,MONAP,NAF,NAP-1,NAP1,SCYB8
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3576
MIM: 146930
HGNC: 6025
Ensembl: ENSG00000169429
Variants:
dbSNP: 3576
ClinVar: 3576
TCGA: ENSG00000169429
COSMIC: CXCL8
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000169429 | ENST00000307407 | P10145 |
| ENSG00000169429 | ENST00000307407 | A0A024RDA5 |
| ENSG00000169429 | ENST00000401931 | C9J4T6 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA130232992 | bevacizumab | Chemical | ClinicalAnnotation | associated | PD | 23584701 | |
| PA134850558 | Macular Degeneration | Disease | ClinicalAnnotation | associated | PD | 23584701 | |
| PA142672077 | CRISPLD2 | Gene | Literature, MultilinkAnnotation | associated | 24926665 | ||
| PA162372840 | sunitinib | Chemical | ClinicalAnnotation | associated | PD | 26387812 | |
| PA443624 | Carcinoma, Renal Cell | Disease | ClinicalAnnotation | associated | PD | 26387812 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37812596 | 2024 | Urinary IL-6 and IL-8 as predictive markers in bladder urothelial carcinoma: A pilot study. | 1 |
| 38006530 | 2024 | Cancer-Associated Fibroblast-Derived IL-8 Upregulates PD-L1 Expression in Gastric Cancer Through the NF-κB Pathway. | 2 |
| 38135806 | 2024 | HIF-1α is an important regulator of IL-8 expression in human bone marrow stromal cells under hypoxic microenvironment. | 1 |
| 38157624 | 2024 | Reduction of IL-6, IL-8 and β2-ADRENOCEPTOR mRNA levels in circulating polymorphonuclear leukocytes after adenotonsillectomy in children with Obstructive Sleep Apnea Syndrome. | 1 |
| 38224035 | 2024 | Interleukin-8 genetic polymorphism and its relation to Helicobacter pylori infection and Helicobacter pylori-associated gastric diseases. | 0 |
| 38233759 | 2024 | Preoperative IL-8 levels as prognostic indicators of overall survival: an extended follow-up in a prospective cohort with colorectal liver metastases. | 0 |
| 38290211 | 2024 | Primary apical periodontitis correlates to elevated levels of interleukin-8 in a Swedish population: A report from the PAROKRANK study. | 0 |
| 38359298 | 2024 | Role of the IL8 rs4073 polymorphism in central nervous system toxicity in patients receiving multidrug-resistant tuberculosis treatment. | 0 |
| 38387232 | 2024 | Interferon-α induces differentiation of cancer stem cells and immunosuppression in hepatocellular carcinoma by upregulating CXCL8 secretion. | 3 |
| 38396325 | 2024 | IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer. | 1 |
| 38426279 | 2024 | CXCL8 and its cognate receptors CXCR1/CXCR2 in primary myelofibrosis. | 0 |
| 38494608 | 2024 | Enhanced lipid biosynthesis in oral squamous cell carcinoma cancer-associated fibroblasts contributes to tumor progression: Role of IL8/AKT/p-ACLY axis. | 1 |
| 38593151 | 2024 | Elevated interleukin-8 expression by skin fibroblasts as a potential contributor to pain in women with Fabry disease. | 1 |
| 38608448 | 2024 | STAT3 promotes cytoplasmic-nuclear translocation of RNA-binding protein HuR to inhibit IL-1β-induced IL-8 production. | 0 |
| 38891100 | 2024 | Interleukin-8/CXCR1 Signaling Contributes to the Progression of Pulmonary Adenocarcinoma Resulting in Malignant Pleural Effusion. | 0 |
Citation
Dessen P
CXCL8 (C-X-C motif chemokine ligand 8)
Atlas Genet Cytogenet Oncol Haematol. 2014-04-01
Online version: http://atlasgeneticsoncology.org/gene/53870/cxcl8-(c-x-c-motif-chemokine-ligand-8)
