Identity
HGNC
LOCATION
8p21.3
LOCUSID
ALIAS
PPP1R38,SH2A
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 63898
MIM: 614968
HGNC: 26102
Ensembl: ENSG00000104611
Variants:
dbSNP: 63898
ClinVar: 63898
TCGA: ENSG00000104611
COSMIC: SH2D4A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000104611 | ENST00000265807 | Q9H788 |
| ENSG00000104611 | ENST00000518040 | Q9H788 |
| ENSG00000104611 | ENST00000519207 | Q9H788 |
| ENSG00000104611 | ENST00000523736 | H0YAT1 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38043670 | 2024 | SH2D4A inhibits esophageal squamous cell carcinoma progression through FAK/PI3K/AKT signaling pathway. | 1 |
| 38043670 | 2024 | SH2D4A inhibits esophageal squamous cell carcinoma progression through FAK/PI3K/AKT signaling pathway. | 1 |
| 34893760 | 2022 | SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer. | 1 |
| 34893760 | 2022 | SH2D4A downregulation due to loss of chromosome 8p is associated with poor prognosis and low T cell infiltration in colorectal cancer. | 1 |
| 27311882 | 2016 | Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma. | 16 |
| 27311882 | 2016 | Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma. | 16 |
| 24315626 | 2014 | SH2D4A is frequently downregulated in hepatocellular carcinoma and cirrhotic nodules. | 5 |
| 24315626 | 2014 | SH2D4A is frequently downregulated in hepatocellular carcinoma and cirrhotic nodules. | 5 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 19712589 | 2009 | SH2D4A regulates cell proliferation via the ERalpha/PLC-gamma/PKC pathway. | 5 |
| 19712589 | 2009 | SH2D4A regulates cell proliferation via the ERalpha/PLC-gamma/PKC pathway. | 5 |
| 18641339 | 2008 | Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells. | 3 |
| 18641339 | 2008 | Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells. | 3 |
Citation
Dessen P
SH2D4A (SH2 domain containing 4A)
Atlas Genet Cytogenet Oncol Haematol. 2014-04-01
Online version: http://atlasgeneticsoncology.org/gene/53879/sh2d4a-(sh2-domain-containing-4a)
