SRP68 (signal recognition particle 68)

2014-05-01  

Identity

HGNC
SRP68
LOCATION
17q25.1
LOCUSID
6730
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6730
MIM: 604858
HGNC: 11302
Ensembl: ENSG00000167881

Variants:

dbSNP: 6730
ClinVar: 6730
TCGA: ENSG00000167881
COSMIC: SRP68

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167881ENST00000307877Q9UHB9
ENSG00000167881ENST00000539137Q9UHB9
ENSG00000167881ENST00000591272K7EQC2
ENSG00000167881ENST00000592704K7EN53
ENSG00000167881ENST00000602720Q9UHB9
ENSG00000167881ENST00000629930K7EN53

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein exportKEGGko03060
Protein exportKEGGhsa03060
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
SRP-dependent cotranslational protein targeting to membraneREACTOMER-HSA-1799339
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
322734752021Identification of biallelic germline variants of SRP68 in a sporadic case with severe congenital neutropenia.5
322734752021Identification of biallelic germline variants of SRP68 in a sporadic case with severe congenital neutropenia.5
306494172019Reconstitution of the human SRP system and quantitative and systematic analysis of its ribosome interactions.16
306494172019Reconstitution of the human SRP system and quantitative and systematic analysis of its ribosome interactions.16
278996662017Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.17
283695292017Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation.13
278996662017Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.17
283695292017Human apo-SRP72 and SRP68/72 complex structures reveal the molecular basis of protein translocation.13
247008612014SRP RNA remodeling by SRP68 explains its role in protein translocation.26
247008612014SRP RNA remodeling by SRP68 explains its role in protein translocation.26
230480282012A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72.8
230480282012A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72.8
166722322006Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains.11
166722322006Protein SRP68 of human signal recognition particle: identification of the RNA and SRP72 binding domains.11

Citation

Dessen P

SRP68 (signal recognition particle 68)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53892/srp68-(signal-recognition-particle-68)