SSH2 (slingshot protein phosphatase 2)

2014-05-01 Affiliation

Identity

HGNC

SSH2

LOCATION

17q11.2

LOCUSID

85464

ALIAS

SSH-2,SSH-2L

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 85464
MIM: 606779
HGNC: 30580
Ensembl: ENSG00000141298

Variants:

dbSNP: 85464
ClinVar: 85464
TCGA: ENSG00000141298
COSMIC: SSH2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000141298	ENST00000269033	Q76I76
ENSG00000141298	ENST00000324677	A0A3B3ITS1
ENSG00000141298	ENST00000540801	F5H527
ENSG00000141298	ENST00000577991	K7EKN7
ENSG00000141298	ENST00000579040	J3KSQ9
ENSG00000141298	ENST00000579954	K7EQZ0
ENSG00000141298	ENST00000582084	J3KSP5
ENSG00000141298	ENST00000590153	J3KSP5
ENSG00000141298	ENST00000592397	K7EP00
ENSG00000141298	ENST00000649863	A0A3B3IS79

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Regulation of actin cytoskeleton	KEGG	ko04810
Axon guidance	KEGG	hsa04360
Regulation of actin cytoskeleton	KEGG	hsa04810

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
30154244	2018	Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot auto-inhibition and activation.	0
30154244	2018	Allosteric modulation of the catalytic VYD loop in Slingshot by its N-terminal domain underlies both Slingshot auto-inhibition and activation.	0
25568344	2015	GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis.	31
25568344	2015	GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis.	31
23416984	2014	Knockdown of Slingshot 2 (SSH2) serine phosphatase induces Caspase3 activation in human carcinoma cell lines with the loss of the Birt-Hogg-Dubé tumour suppressor gene (FLCN).	6
23416984	2014	Knockdown of Slingshot 2 (SSH2) serine phosphatase induces Caspase3 activation in human carcinoma cell lines with the loss of the Birt-Hogg-Dubé tumour suppressor gene (FLCN).	6
20477815	2010	Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability.	5
20477815	2010	Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability.	5
17848544	2007	The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes.	44
17848544	2007	The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes.	44

Citation

Dessen P

SSH2 (slingshot protein phosphatase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53893/ssh2-(slingshot-protein-phosphatase-2)