SUOX (sulfite oxidase)

2014-05-01  

Identity

HGNC
SUOX
LOCATION
12q13.2
LOCUSID
6821
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6821
MIM: 606887
HGNC: 11460
Ensembl: ENSG00000139531

Variants:

dbSNP: 6821
ClinVar: 6821
TCGA: ENSG00000139531
COSMIC: SUOX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139531ENST00000266971P51687
ENSG00000139531ENST00000266971A0A024RB79
ENSG00000139531ENST00000356124P51687
ENSG00000139531ENST00000356124A0A024RB79
ENSG00000139531ENST00000394109P51687
ENSG00000139531ENST00000394109A0A024RB79
ENSG00000139531ENST00000394115P51687
ENSG00000139531ENST00000394115A0A024RB79
ENSG00000139531ENST00000546833F8VVW9
ENSG00000139531ENST00000547586F8VRK9
ENSG00000139531ENST00000548274P51687
ENSG00000139531ENST00000548274A0A024RB79
ENSG00000139531ENST00000550065P51687
ENSG00000139531ENST00000550065A0A024RB79
ENSG00000139531ENST00000551841F8VX56
ENSG00000139531ENST00000552258F8VPA2

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Sulfur metabolismKEGGko00920
Sulfur metabolismKEGGhsa00920
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Sulfur amino acid metabolismREACTOMER-HSA-1614635
Degradation of cysteine and homocysteineREACTOMER-HSA-1614558
Sulfide oxidation to sulfateREACTOMER-HSA-1614517

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371870152023Epilepsy in sulfite oxidase deficiency and related disorders: insights from neuroimaging and genetics.1
374419222023Mechanistic complexities of sulfite oxidase: An enzyme with multiple domains, subunits, and cofactors.1
371870152023Epilepsy in sulfite oxidase deficiency and related disorders: insights from neuroimaging and genetics.1
374419222023Mechanistic complexities of sulfite oxidase: An enzyme with multiple domains, subunits, and cofactors.1
358962562022Predictive and Prognostic Value of SUOX Expression in Pancreatic Ductal Adenocarcinoma.0
358962562022Predictive and Prognostic Value of SUOX Expression in Pancreatic Ductal Adenocarcinoma.0
341170752021Postmortem whole-genome sequencing on a dried blood spot identifies a novel homozygous SUOX variant causing isolated sulfite oxidase deficiency.1
341170752021Postmortem whole-genome sequencing on a dried blood spot identifies a novel homozygous SUOX variant causing isolated sulfite oxidase deficiency.1
306319482019High sulfite oxidase expression could predict postoperative biochemical recurrence in patients with prostate cancer.3
311279342019Impaired mitochondrial maturation of sulfite oxidase in a patient with severe sulfite oxidase deficiency.8
306319482019High sulfite oxidase expression could predict postoperative biochemical recurrence in patients with prostate cancer.3
311279342019Impaired mitochondrial maturation of sulfite oxidase in a patient with severe sulfite oxidase deficiency.8
292800122018SUOX is negatively associated with multistep carcinogenesis and proliferation in oral squamous cell carcinoma.5
292800122018SUOX is negatively associated with multistep carcinogenesis and proliferation in oral squamous cell carcinoma.5
286294182017Prenatal brain disruption in isolated sulfite oxidase deficiency.5

Citation

Dessen P

SUOX (sulfite oxidase)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53894/suox-(sulfite-oxidase)