MYO10 (myosin X)

2014-05-01  

Identity

HGNC
LOCATION
5p15.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 4651
MIM: 601481
HGNC: 7593
Ensembl: ENSG00000145555

Variants:

dbSNP: 4651
ClinVar: 4651
TCGA: ENSG00000145555
COSMIC: MYO10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145555ENST00000274203A0A0A0MQX1
ENSG00000145555ENST00000502436E9PCN3
ENSG00000145555ENST00000505695E9PEW5
ENSG00000145555ENST00000507288Q9HD67
ENSG00000145555ENST00000513610Q9HD67
ENSG00000145555ENST00000513882D6RGD1
ENSG00000145555ENST00000515803E9PEW5

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
168941632006Myosin-X is a molecular motor that functions in filopodia formation.124
151584642004Myosin X transports Mena/VASP to the tip of filopodia.73
185994512008A myosin motor that selects bundled actin for motility.70
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.63
244875862014Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
262350482015Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds.37
209301422010PtdIns(3,4,5)P₃ is a regulator of myosin-X localization and filopodia formation.35
201239702010The motor protein myosin-X transports VE-cadherin along filopodia to allow the formation of early endothelial cell-cell contacts.34
213212302011Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain.33

Citation

Dessen P

MYO10 (myosin X)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53906/myo10-(myosin-x)