TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2)

2014-05-01  

Identity

HGNC
LOCATION
17q23.2
LOCUSID
ALIAS
IDDALDS,ROLSA,rols
FUSION GENES

Other Information

Locus ID:

NCBI: 26115
MIM: 615047
HGNC: 30212
Ensembl: ENSG00000170921

Variants:

dbSNP: 26115
ClinVar: 26115
TCGA: ENSG00000170921
COSMIC: TANC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170921ENST00000389520Q9HCD6
ENSG00000170921ENST00000424789Q9HCD6
ENSG00000170921ENST00000580068J3KTM5
ENSG00000170921ENST00000580466J3QQY7
ENSG00000170921ENST00000583016J3QRF0
ENSG00000170921ENST00000583356J3KRP9

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10407calcium channel blockersChemicalClinicalAnnotationassociatedPD24192120
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD24192120

References

Pubmed IDYearTitleCitations
223604202012Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.18
241488222014A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation.14
316160002019Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders.2

Citation

Dessen P

TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53914/tanc2-(tetratricopeptide-repeat-ankyrin-repeat-and-coiled-coil-containing-2)