CISD1 (CDGSH iron sulfur domain 1)

2013-12-01  

Identity

HGNC
LOCATION
10q21.1
LOCUSID
ALIAS
C10orf70,MDS029,ZCD1,mitoNEET
FUSION GENES

Other Information

Locus ID:

NCBI: 55847
MIM: 611932
HGNC: 30880
Ensembl: ENSG00000122873

Variants:

dbSNP: 55847
ClinVar: 55847
TCGA: ENSG00000122873
COSMIC: CISD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122873ENST00000333926Q9NZ45
ENSG00000122873ENST00000333926A0A024QZN7

Expression (GTEx)

0
5
10
15
20
25
30
35
40

References

Pubmed IDYearTitleCitations
173768632007MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity.101
177664402007MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone.97
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
175847442007The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster.54
239598812013NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth.53
177664392007Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins.50
217884812011Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor protein.45
179057432007Crystallographic studies of human MitoNEET.41
254480352015Structure-function analysis of NEET proteins uncovers their role as key regulators of iron and ROS homeostasis in health and disease.41
275106392016CISD1 inhibits ferroptosis by protection against mitochondrial lipid peroxidation.37

Citation

Dessen P

CISD1 (CDGSH iron sulfur domain 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-12-01

Online version: http://atlasgeneticsoncology.org/gene/53917/cisd1-(cdgsh-iron-sulfur-domain-1)