ADD1 (adducin 1)

2014-02-01 Affiliation

Identity

HGNC

ADD1

LOCATION

4p16.3

LOCUSID

118

ALIAS

ADDA

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 118
MIM: 102680
HGNC: 243
Ensembl: ENSG00000087274

Variants:

dbSNP: 118
ClinVar: 118
TCGA: ENSG00000087274
COSMIC: ADD1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000087274	ENST00000264758	P35611
ENSG00000087274	ENST00000355842	P35611
ENSG00000087274	ENST00000398123	P35611
ENSG00000087274	ENST00000398125	P35611
ENSG00000087274	ENST00000398129	P35611
ENSG00000087274	ENST00000446856	A0A0A0MSR2
ENSG00000087274	ENST00000503455	E7ENY0
ENSG00000087274	ENST00000508277	D6RF25
ENSG00000087274	ENST00000510101	D6RJE2
ENSG00000087274	ENST00000511797	D6RAH3
ENSG00000087274	ENST00000513328	E7EV99
ENSG00000087274	ENST00000514940	H0Y9H2
ENSG00000087274	ENST00000536424	H0YFD8
ENSG00000087274	ENST00000541843	H0YG19
ENSG00000087274	ENST00000651918	P35611

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Unfolded Protein Response (UPR)	REACTOME	R-HSA-381119
IRE1alpha activates chaperones	REACTOME	R-HSA-381070
XBP1(S) activates chaperone genes	REACTOME	R-HSA-381038
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Miscellaneous transport and binding events	REACTOME	R-HSA-5223345
Programmed Cell Death	REACTOME	R-HSA-5357801
Apoptosis	REACTOME	R-HSA-109581
Apoptotic execution phase	REACTOME	R-HSA-75153
Apoptotic cleavage of cellular proteins	REACTOME	R-HSA-111465
Caspase-mediated cleavage of cytoskeletal proteins	REACTOME	R-HSA-264870

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA151249535	diuretics	Chemical	ClinicalAnnotation	associated	PD	11926892, 17189961
PA444552	Hypertension	Disease	ClinicalAnnotation	associated	PD	10523341, 11882573, 11926892, 12623934, 14553962, 17189961, 18591455, 19057513, 9149697
PA444797	Liver Cirrhosis	Disease	ClinicalAnnotation	associated	PD	21692745
PA445019	Myocardial Infarction	Disease	ClinicalAnnotation	associated	PD	11926892, 17189961
PA447288	Essential hypertension	Disease	ClinicalAnnotation	associated	PD	10523341, 11882573, 12623934, 14553962, 18591455, 19057513, 9149697
PA448682	bumetanide	Chemical	ClinicalAnnotation	associated	PD	20877298
PA449719	furosemide	Chemical	ClinicalAnnotation	associated	PD	20877298, 21692745
PA449899	hydrochlorothiazide	Chemical	ClinicalAnnotation	associated	PD	10523341, 11882573, 12623934, 14553962, 18591455, 19057513, 9149697
PA451483	spironolactone	Chemical	ClinicalAnnotation	associated	PD	21692745
PA451733	torasemide	Chemical	ClinicalAnnotation	associated	PD	20877298
PA62	ATP1A1	Gene	Pathway	associated		23788015

References

Pubmed ID	Year	Title	Citations
34859687	2022	The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension-vascular, renal, and cognitive diseases.	5
34859687	2022	The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension-vascular, renal, and cognitive diseases.	5
31943323	2020	Letter to the editor: Association between α-adducin rs4961 polymorphism and hypertension: A meta-analysis based on 40 432 subjects.	0
32237935	2020	Increased expression of phosphorylated adducin in tumor cells.	0
32971583	2020	Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis.	4
31943323	2020	Letter to the editor: Association between α-adducin rs4961 polymorphism and hypertension: A meta-analysis based on 40 432 subjects.	0
32237935	2020	Increased expression of phosphorylated adducin in tumor cells.	0
32971583	2020	Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis.	4
30062972	2019	Alpha Adducin (ADD1) Gene Polymorphism and New Onset of Diabetes Under the Influence of Selective Antihypertensive Therapy in Essential Hypertension.	2
30552709	2019	Association between α-adducin rs4961 polymorphism and hypertension: A meta-analysis based on 40 432 subjects.	5
30062972	2019	Alpha Adducin (ADD1) Gene Polymorphism and New Onset of Diabetes Under the Influence of Selective Antihypertensive Therapy in Essential Hypertension.	2
30552709	2019	Association between α-adducin rs4961 polymorphism and hypertension: A meta-analysis based on 40 432 subjects.	5
29925526	2018	Adducin-1 is essential for spindle pole integrity through its interaction with TPX2.	7
29925526	2018	Adducin-1 is essential for spindle pole integrity through its interaction with TPX2.	7
28686109	2017	α-Adducin gene promoter DNA methylation and the risk of essential hypertension.	4

Citation

Dessen P

ADD1 (adducin 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53920/add1-(adducin-1)