Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 118
MIM: 102680
HGNC: 243
Ensembl: ENSG00000087274
Variants:
dbSNP: 118
ClinVar: 118
TCGA: ENSG00000087274
COSMIC: ADD1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA151249535 | diuretics | Chemical | ClinicalAnnotation | associated | PD | 11926892, 17189961 | |
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 10523341, 11882573, 11926892, 12623934, 14553962, 17189961, 18591455, 19057513, 9149697 | |
| PA444797 | Liver Cirrhosis | Disease | ClinicalAnnotation | associated | PD | 21692745 | |
| PA445019 | Myocardial Infarction | Disease | ClinicalAnnotation | associated | PD | 11926892, 17189961 | |
| PA447288 | Essential hypertension | Disease | ClinicalAnnotation | associated | PD | 10523341, 11882573, 12623934, 14553962, 18591455, 19057513, 9149697 | |
| PA448682 | bumetanide | Chemical | ClinicalAnnotation | associated | PD | 20877298 | |
| PA449719 | furosemide | Chemical | ClinicalAnnotation | associated | PD | 20877298, 21692745 | |
| PA449899 | hydrochlorothiazide | Chemical | ClinicalAnnotation | associated | PD | 10523341, 11882573, 12623934, 14553962, 18591455, 19057513, 9149697 | |
| PA451483 | spironolactone | Chemical | ClinicalAnnotation | associated | PD | 21692745 | |
| PA451733 | torasemide | Chemical | ClinicalAnnotation | associated | PD | 20877298 | |
| PA62 | ATP1A1 | Gene | Pathway | associated | 23788015 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34859687 | 2022 | The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension-vascular, renal, and cognitive diseases. | 5 |
| 34859687 | 2022 | The adducin saga: pleiotropic genomic targets for precision medicine in human hypertension-vascular, renal, and cognitive diseases. | 5 |
| 31943323 | 2020 | Letter to the editor: Association between α-adducin rs4961 polymorphism and hypertension: A meta-analysis based on 40 432 subjects. | 0 |
| 32237935 | 2020 | Increased expression of phosphorylated adducin in tumor cells. | 0 |
| 32971583 | 2020 | Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis. | 4 |
| 31943323 | 2020 | Letter to the editor: Association between α-adducin rs4961 polymorphism and hypertension: A meta-analysis based on 40 432 subjects. | 0 |
| 32237935 | 2020 | Increased expression of phosphorylated adducin in tumor cells. | 0 |
| 32971583 | 2020 | Association of TBXA2R, P2Y12 and ADD1 genes polymorphisms with ischemic stroke susceptibility: A metaanalysis. | 4 |
| 30062972 | 2019 | Alpha Adducin (ADD1) Gene Polymorphism and New Onset of Diabetes Under the Influence of Selective Antihypertensive Therapy in Essential Hypertension. | 2 |
| 30552709 | 2019 | Association between α-adducin rs4961 polymorphism and hypertension: A meta-analysis based on 40 432 subjects. | 5 |
| 30062972 | 2019 | Alpha Adducin (ADD1) Gene Polymorphism and New Onset of Diabetes Under the Influence of Selective Antihypertensive Therapy in Essential Hypertension. | 2 |
| 30552709 | 2019 | Association between α-adducin rs4961 polymorphism and hypertension: A meta-analysis based on 40 432 subjects. | 5 |
| 29925526 | 2018 | Adducin-1 is essential for spindle pole integrity through its interaction with TPX2. | 7 |
| 29925526 | 2018 | Adducin-1 is essential for spindle pole integrity through its interaction with TPX2. | 7 |
| 28686109 | 2017 | α-Adducin gene promoter DNA methylation and the risk of essential hypertension. | 4 |
Citation
Dessen P
ADD1 (adducin 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-02-01
Online version: http://atlasgeneticsoncology.org/gene/53920/add1-(adducin-1)
