EFNA3 (ephrin A3)

2014-06-01  

Identity

HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
EFL2,EPLG3,Ehk1-L,LERK3
FUSION GENES

Other Information

Locus ID:

NCBI: 1944
MIM: 601381
HGNC: 3223
Ensembl: ENSG00000143590

Variants:

dbSNP: 1944
ClinVar: 1944
TCGA: ENSG00000143590
COSMIC: EFNA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143590ENST00000368408P52797

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
357709492023EphrinA3 is a key regulator of malignant behaviors and a potential prognostic factor in lung adenocarcinoma.6
357709492023EphrinA3 is a key regulator of malignant behaviors and a potential prognostic factor in lung adenocarcinoma.6
352277732022Ephrin-A3/EphA2 axis regulates cellular metabolic plasticity to enhance cancer stemness in hypoxic hepatocellular carcinoma.29
353459802022LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis.3
358504842022Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K pathway.28
361916062022Hsa_circ_0007478 aggravates NLRP3 inflammasome activation and lipid metabolism imbalance in ox-LDL-stimulated macrophage via miR-765/EFNA3 axis.8
352277732022Ephrin-A3/EphA2 axis regulates cellular metabolic plasticity to enhance cancer stemness in hypoxic hepatocellular carcinoma.29
353459802022LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis.3
358504842022Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K pathway.28
361916062022Hsa_circ_0007478 aggravates NLRP3 inflammasome activation and lipid metabolism imbalance in ox-LDL-stimulated macrophage via miR-765/EFNA3 axis.8
346186212021Role of EphrinA3 in HIV-1 Neuropathogenesis.0
346186212021Role of EphrinA3 in HIV-1 Neuropathogenesis.0
321803532020MiR-210-3p-EphrinA3-PI3K/AKT axis regulates the progression of oral cancer.23
326958102020OSCC Exosomes Regulate miR-210-3p Targeting EFNA3 to Promote Oral Cancer Angiogenesis through the PI3K/AKT Pathway.41
321803532020MiR-210-3p-EphrinA3-PI3K/AKT axis regulates the progression of oral cancer.23

Citation

Dessen P

EFNA3 (ephrin A3)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53933/efna3-(ephrin-a3)