AZIN2 (antizyme inhibitor 2)

2014-06-01  

Identity

HGNC
AZIN2
LOCATION
1p35.1
LOCUSID
113451
ALIAS
ADC,AZI2,AZIB1,ODC-p,ODC1L,ODCp
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 113451
MIM: 608353
HGNC: 29957
Ensembl: ENSG00000142920

Variants:

dbSNP: 113451
ClinVar: 113451
TCGA: ENSG00000142920
COSMIC: AZIN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142920ENST00000294517Q96A70
ENSG00000142920ENST00000373440A0A499FIG4
ENSG00000142920ENST00000373441Q96A70
ENSG00000142920ENST00000373443Q96A70
ENSG00000142920ENST00000652171A0A494BZU1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
Polyamine biosynthesis, arginine => agmatine => putrescine => spermidineKEGGhsa_M00133
Polyamine biosynthesis, arginine => agmatine => putrescine => spermidineKEGGM00133
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Agmatine biosynthesisREACTOMER-HSA-351143

References

Pubmed IDYearTitleCitations
378994972024Enhanced anti-tumor activity of arginine decarboxylase through the incorporation of aromatic amino acids at the multimer-forming interface.0
378994972024Enhanced anti-tumor activity of arginine decarboxylase through the incorporation of aromatic amino acids at the multimer-forming interface.0
335866802021Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.18
340469262021Antizyme inhibitor 2 (AZIN2) associates with better prognosis of head and neck minor salivary gland adenoid cystic carcinoma.1
335866802021Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology.18
340469262021Antizyme inhibitor 2 (AZIN2) associates with better prognosis of head and neck minor salivary gland adenoid cystic carcinoma.1
295848192018Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration.35
295848192018Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration.35
269638402016Expression of ODC Antizyme Inhibitor 2 (AZIN2) in Human Secretory Cells and Tissues.11
275914822016Transfection of arginine decarboxylase gene increases the neuronal differentiation of neural progenitor cells.6
269638402016Expression of ODC Antizyme Inhibitor 2 (AZIN2) in Human Secretory Cells and Tissues.11
275914822016Transfection of arginine decarboxylase gene increases the neuronal differentiation of neural progenitor cells.6
198328402010Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease.19
199569902010Antizyme inhibitor 2: molecular, cellular and physiological aspects.15
201479692010Non-synonymous single-nucleotide polymorphisms associated with blood pressure and hypertension.20

Citation

Dessen P

AZIN2 (antizyme inhibitor 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53943/azin2-(antizyme-inhibitor-2)