AZIN2 (antizyme inhibitor 2)

2014-06-01  

Identity

HGNC
LOCATION
1p35.1
LOCUSID
ALIAS
ADC,AZI2,AZIB1,ODC-p,ODC1L,ODCp
FUSION GENES

Other Information

Locus ID:

NCBI: 113451
MIM: 608353
HGNC: 29957
Ensembl: ENSG00000142920

Variants:

dbSNP: 113451
ClinVar: 113451
TCGA: ENSG00000142920
COSMIC: AZIN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142920ENST00000294517Q96A70
ENSG00000142920ENST00000373440A0A499FIG4
ENSG00000142920ENST00000373441Q96A70
ENSG00000142920ENST00000373443Q96A70
ENSG00000142920ENST00000652171A0A494BZU1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
Polyamine biosynthesis, arginine => agmatine => putrescine => spermidineKEGGhsa_M00133
Polyamine biosynthesis, arginine => agmatine => putrescine => spermidineKEGGM00133
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Agmatine biosynthesisREACTOMER-HSA-351143

References

Pubmed IDYearTitleCitations
201479692010Non-synonymous single-nucleotide polymorphisms associated with blood pressure and hypertension.16
295848192018Loss of AZIN2 splice variant facilitates endogenous cardiac regeneration.13
198328402010Brain neurons express ornithine decarboxylase-activating antizyme inhibitor 2 with accumulation in Alzheimer's disease.11
199569902010Antizyme inhibitor 2: molecular, cellular and physiological aspects.11
201887282010Ornithine decarboxylase antizyme inhibitor 2 regulates intracellular vesicle trafficking.10
197566942009High expression of antizyme inhibitor 2, an activator of ornithine decarboxylase in steroidogenic cells of human gonads.8
269638402016Expression of ODC Antizyme Inhibitor 2 (AZIN2) in Human Secretory Cells and Tissues.6
275914822016Transfection of arginine decarboxylase gene increases the neuronal differentiation of neural progenitor cells.4

Citation

Dessen P

AZIN2 (antizyme inhibitor 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53943/azin2-(antizyme-inhibitor-2)