PDIA5 (protein disulfide isomerase family A member 5)

2014-06-01  

Identity

HGNC
PDIA5
LOCATION
3q21.1
LOCUSID
10954
ALIAS
PDIR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10954
MIM: 616942
HGNC: 24811
Ensembl: ENSG00000065485

Variants:

dbSNP: 10954
ClinVar: 10954
TCGA: ENSG00000065485
COSMIC: PDIA5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065485ENST00000316218Q14554
ENSG00000065485ENST00000469649H7C4F9
ENSG00000065485ENST00000484644C9JY10
ENSG00000065485ENST00000489923Q14554

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
360034002022Pan-Cancer Analysis of the Immunological Role of PDIA5: A Potential Target for Immunotherapy.2
360034002022Pan-Cancer Analysis of the Immunological Role of PDIA5: A Potential Target for Immunotherapy.2
336647472021PDIA5 is Correlated With Immune Infiltration and Predicts Poor Prognosis in Gliomas.31
336647472021PDIA5 is Correlated With Immune Infiltration and Predicts Poor Prognosis in Gliomas.31
292934532018Contribution of activated beta3 integrin in the PDI release from endothelial cells.9
292934532018Contribution of activated beta3 integrin in the PDI release from endothelial cells.9
240370322014Protein disulfide isomerase P5-immunopositive inclusions in patients with Alzheimer's disease.11
246369892014Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance.97
240370322014Protein disulfide isomerase P5-immunopositive inclusions in patients with Alzheimer's disease.11
246369892014Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance.97
220024442012Unfolded protein response is not activated in the mucopolysaccharidoses but protein disulfide isomerase 5 is deregulated.11
220024442012Unfolded protein response is not activated in the mucopolysaccharidoses but protein disulfide isomerase 5 is deregulated.11
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
207960292010A structural overview of the PDI family of proteins.114
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

PDIA5 (protein disulfide isomerase family A member 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53962/pdia5-(protein-disulfide-isomerase-family-a-member-5)