SPOCK2 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2)

2014-06-01  

Identity

HGNC
SPOCK2
LOCATION
10q22.1
LOCUSID
9806
ALIAS
testican-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9806
MIM: 607988
HGNC: 13564
Ensembl: ENSG00000107742

Variants:

dbSNP: 9806
ClinVar: 9806
TCGA: ENSG00000107742
COSMIC: SPOCK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107742ENST00000317376Q92563
ENSG00000107742ENST00000373109Q92563
ENSG00000107742ENST00000412663Q92563
ENSG00000107742ENST00000536168F5H283

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
388881962024The novel prognostic marker SPOCK2 regulates tumour progression in melanoma.0
388881962024The novel prognostic marker SPOCK2 regulates tumour progression in melanoma.0
362889052023Testican-2 Is Associated with Reduced Risk of Incident ESKD.5
366299842023SPOCK2 and SPRED1 function downstream of EZH2 to impede the malignant progression of lung adenocarcinoma in vitro and in vivo.2
371653782023Integrated bulk and single-cell RNA-sequencing reveals SPOCK2 as a novel biomarker gene in the development of congenital pulmonary airway malformation.1
371889842023SPOCK2 gene expression is downregulated in pancreatic ductal adenocarcinoma cells and correlates with prognosis of patients with pancreatic cancer.0
362889052023Testican-2 Is Associated with Reduced Risk of Incident ESKD.5
366299842023SPOCK2 and SPRED1 function downstream of EZH2 to impede the malignant progression of lung adenocarcinoma in vitro and in vivo.2
371653782023Integrated bulk and single-cell RNA-sequencing reveals SPOCK2 as a novel biomarker gene in the development of congenital pulmonary airway malformation.1
371889842023SPOCK2 gene expression is downregulated in pancreatic ductal adenocarcinoma cells and correlates with prognosis of patients with pancreatic cancer.0
328518932021Downregulation of SPOCK2 promotes the proliferation, adhesion, and invasion of endometrial epithelial cells.0
328518932021Downregulation of SPOCK2 promotes the proliferation, adhesion, and invasion of endometrial epithelial cells.0
324307152020SPOCK2 Affects the Biological Behavior of Endometrial Cancer Cells by Regulation of MT1-MMP and MMP2.10
329586452020Circulating testican-2 is a podocyte-derived marker of kidney health.15
324307152020SPOCK2 Affects the Biological Behavior of Endometrial Cancer Cells by Regulation of MT1-MMP and MMP2.10

Citation

Dessen P

SPOCK2 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53964/spock2-(sparc-(osteonectin)-cwcv-and-kazal-like-domains-proteoglycan-2)