DOCK4 (dedicator of cytokinesis 4)

2014-06-01  

Identity

HGNC
DOCK4
LOCATION
7q31.1
LOCUSID
9732
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9732
MIM: 607679
HGNC: 19192
Ensembl: ENSG00000128512

Variants:

dbSNP: 9732
ClinVar: 9732
TCGA: ENSG00000128512
COSMIC: DOCK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128512ENST00000417165C9JDB3
ENSG00000128512ENST00000423057H0Y7H7
ENSG00000128512ENST00000428053F8WES4
ENSG00000128512ENST00000428084Q8N1I0
ENSG00000128512ENST00000437129C9J7D9
ENSG00000128512ENST00000437633Q8N1I0
ENSG00000128512ENST00000445943H0Y599
ENSG00000128512ENST00000450156C9J637
ENSG00000128512ENST00000494651F5GXW1
ENSG00000128512ENST00000658652A0A590UJ51
ENSG00000128512ENST00000664131A0A590UJM5

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

References

Pubmed IDYearTitleCitations
384439232024Integration analysis of lncRNA and mRNA expression data identifies DOCK4 as a potential biomarker for elderly osteoporosis.0
385267442024Heterozygous loss-of-function variants in DOCK4 cause neurodevelopmental delay and microcephaly.0
384439232024Integration analysis of lncRNA and mRNA expression data identifies DOCK4 as a potential biomarker for elderly osteoporosis.0
385267442024Heterozygous loss-of-function variants in DOCK4 cause neurodevelopmental delay and microcephaly.0
368225132023Genetic variations in DOCK4 contribute to schizophrenia susceptibility in a Chinese cohort: A genetic neuroimaging study.0
368225132023Genetic variations in DOCK4 contribute to schizophrenia susceptibility in a Chinese cohort: A genetic neuroimaging study.0
353021842022DOCK4 regulates ghrelin production in gastric X/A-like cells.0
353021842022DOCK4 regulates ghrelin production in gastric X/A-like cells.0
335591552021DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation.12
335591552021DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation.12
325766932020Up-regulated cytotrophoblast DOCK4 contributes to over-invasion in placenta accreta spectrum.10
325766932020Up-regulated cytotrophoblast DOCK4 contributes to over-invasion in placenta accreta spectrum.10
310193072019SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.124
310193072019SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis.124
289253992018DOCK4 promotes loss of proliferation in glioblastoma progenitor cells through nuclear beta-catenin accumulation and subsequent miR-302-367 cluster expression.16

Citation

Dessen P

DOCK4 (dedicator of cytokinesis 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53973/dock4-(dedicator-of-cytokinesis-4)