RPS19BP1 (ribosomal protein S19 binding protein 1)

2014-06-01  

Identity

HGNC
RPS19BP1
LOCATION
22q13.1
LOCUSID
91582
ALIAS
AROS,S19BP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 91582
MIM: 610225
HGNC: 28749
Ensembl: ENSG00000187051

Variants:

dbSNP: 91582
ClinVar: 91582
TCGA: ENSG00000187051
COSMIC: RPS19BP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187051ENST00000334678Q86WX3
ENSG00000187051ENST00000334678A0A024R1T1
ENSG00000187051ENST00000420879F8WFE7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
179642662007Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity.160
233498632013The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response.17
235483082013Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol.8
242582752013Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity.7
246810972014AROS has a context-dependent effect on SIRT1.3
297338582018The Legionella pneumophila Methyltransferase RomA Methylates Also Non-histone Proteins during Infection.3
263391642015AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma.2

Citation

Dessen P

RPS19BP1 (ribosomal protein S19 binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53979/rps19bp1-(ribosomal-protein-s19-binding-protein-1)