NFIA (nuclear factor I A)

2014-06-01  

Identity

HGNC
LOCATION
1p31.3
LOCUSID
ALIAS
BRMUTD,CTF,NF-I/A,NF1-A,NFI-A,NFI-L
FUSION GENES

Other Information

Locus ID:

NCBI: 4774
MIM: 600727
HGNC: 7784
Ensembl: ENSG00000162599

Variants:

dbSNP: 4774
ClinVar: 4774
TCGA: ENSG00000162599
COSMIC: NFIA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162599ENST00000357977S4R3K5
ENSG00000162599ENST00000371184B1AKN6
ENSG00000162599ENST00000371185B1AKN5
ENSG00000162599ENST00000371187Q12857
ENSG00000162599ENST00000371189Q12857
ENSG00000162599ENST00000371191B1AKN8
ENSG00000162599ENST00000403491Q12857
ENSG00000162599ENST00000407417Q12857
ENSG00000162599ENST00000476646S4R3K4
ENSG00000162599ENST00000482020S4R3W2
ENSG00000162599ENST00000485903B1AKN7
ENSG00000162599ENST00000493627S4R3W6
ENSG00000162599ENST00000496712S4R308
ENSG00000162599ENST00000655770A0A590UJA3
ENSG00000162599ENST00000657234A0A590UK38
ENSG00000162599ENST00000662015A0A590UJ82
ENSG00000162599ENST00000663597A0A590UJU2
ENSG00000162599ENST00000664149A0A590UK09
ENSG00000162599ENST00000664495A0A590UJ67
ENSG00000162599ENST00000670151A0A590UK73

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription TerminationREACTOMER-HSA-73980

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163255772005A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis.358
105185561999Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum.85
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
252656442015RP5-833A20.1/miR-382-5p/NFIA-dependent signal transduction pathway contributes to the regulation of cholesterol homeostasis and inflammatory reaction.49
175309272007NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects.37
155988222004Distributions of Z-DNA and nuclear factor I in human chromosome 22: a model for coupled transcriptional regulation.22
195408482009Nuclear factor I regulates brain fatty acid-binding protein and glial fibrillary acidic protein gene expression in malignant glioma cell lines.22
239464142013The miR-223/nuclear factor I-A axis regulates glial precursor proliferation and tumorigenesis in the CNS.22
195423022009NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls beta-globin and G-CSF receptor expression.21

Citation

Dessen P

NFIA (nuclear factor I A)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53987/nfia-(nuclear-factor-i-a)