FERMT3 (FERM domain containing kindlin 3)

2014-06-01  

Identity

HGNC
FERMT3
LOCATION
11q13.1
LOCUSID
83706
ALIAS
KIND3,MIG-2,MIG2B,UNC112C,URP2,URP2SF

Other Information

Locus ID:

NCBI: 83706
MIM: 607901
HGNC: 23151
Ensembl: ENSG00000149781

Variants:

dbSNP: 83706
ClinVar: 83706
TCGA: ENSG00000149781
COSMIC: FERMT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149781ENST00000279227Q86UX7
ENSG00000149781ENST00000345728Q86UX7
ENSG00000149781ENST00000541252F5H3I6
ENSG00000149781ENST00000544997F5H1C6
ENSG00000149781ENST00000545896H0YFT5

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Platelet activationKEGGhsa04611
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

References

Pubmed IDYearTitleCitations
382558222024Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.0
385706922024Inactivation of kindlin-3 increases human melanoma aggressiveness through the collagen-activated tyrosine kinase receptor DDR1.0
382558222024Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.0
385706922024Inactivation of kindlin-3 increases human melanoma aggressiveness through the collagen-activated tyrosine kinase receptor DDR1.0
366485752023A Novel Deletion in FERMT3 Causes LAD-III in a Turkish Family.1
366495862023Kindlin-3 deficiency leads to impaired erythropoiesis and erythrocyte cytoskeleton.0
366485752023A Novel Deletion in FERMT3 Causes LAD-III in a Turkish Family.1
366495862023Kindlin-3 deficiency leads to impaired erythropoiesis and erythrocyte cytoskeleton.0
356729072022Blockage of PD-L1 by FERMT3-mediated Wnt/β-catenin signalling regulates chemoresistance and immune evasion of colorectal cancer cells.3
356729072022Blockage of PD-L1 by FERMT3-mediated Wnt/β-catenin signalling regulates chemoresistance and immune evasion of colorectal cancer cells.3
327778222021Kindlin-3 recruitment to the plasma membrane precedes high-affinity β2-integrin and neutrophil arrest from rolling.25
334179212021Kindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis.7
337835642021Kindlin3 regulates biophysical properties and mechanics of membrane to cortex attachment.5
347422982021FERMT3 mediates cigarette smoke-induced epithelial-mesenchymal transition through Wnt/β-catenin signaling.9
350486362021Kindlin-3 and RASSF6 are probable biomarkers for predicting metastasis in cutaneous melanoma.0

Citation

Dessen P

FERMT3 (FERM domain containing kindlin 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53989/fermt3-(ferm-domain-containing-kindlin-3)