Identity
HGNC
LOCATION
12q23.3
LOCUSID
ALIAS
2310020H20Rik,HML,ISU2,NIFU,NIFUN,hnifU
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23479
MIM: 611911
HGNC: 29882
Ensembl: ENSG00000136003
Variants:
dbSNP: 23479
ClinVar: 23479
TCGA: ENSG00000136003
COSMIC: ISCU
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Mitochondrial iron-sulfur cluster biogenesis | REACTOME | R-HSA-1362409 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37225108 | 2023 | Copper exerts cytotoxicity through inhibition of iron-sulfur cluster biogenesis on ISCA1/ISCA2/ISCU assembly proteins. | 2 |
| 37225108 | 2023 | Copper exerts cytotoxicity through inhibition of iron-sulfur cluster biogenesis on ISCA1/ISCA2/ISCU assembly proteins. | 2 |
| 33562493 | 2021 | Characterization and Reconstitution of Human Lipoyl Synthase (LIAS) Supports ISCA2 and ISCU as Primary Cluster Donors and an Ordered Mechanism of Cluster Assembly. | 11 |
| 34824239 | 2021 | N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization. | 11 |
| 33562493 | 2021 | Characterization and Reconstitution of Human Lipoyl Synthase (LIAS) Supports ISCA2 and ISCU as Primary Cluster Donors and an Ordered Mechanism of Cluster Assembly. | 11 |
| 34824239 | 2021 | N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization. | 11 |
| 32495170 | 2020 | rs2072580T>A Polymorphism in the Overlapping Promoter Regions of the SART3 and ISCU Genes Associated with the Risk of Breast Cancer. | 0 |
| 32495170 | 2020 | rs2072580T>A Polymorphism in the Overlapping Promoter Regions of the SART3 and ISCU Genes Associated with the Risk of Breast Cancer. | 0 |
| 31101807 | 2019 | Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism. | 62 |
| 31101807 | 2019 | Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism. | 62 |
| 29406711 | 2018 | ISCU(M108I) and ISCU(D39V) Differ from Wild-Type ISCU in Their Failure To Form Cysteine Desulfurase Complexes Containing Both Frataxin and Ferredoxin. | 11 |
| 30031876 | 2018 | Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity. | 11 |
| 29406711 | 2018 | ISCU(M108I) and ISCU(D39V) Differ from Wild-Type ISCU in Their Failure To Form Cysteine Desulfurase Complexes Containing Both Frataxin and Ferredoxin. | 11 |
| 30031876 | 2018 | Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity. | 11 |
| 28271877 | 2017 | The N-Terminus of Iron-Sulfur Cluster Assembly Factor ISD11 Is Crucial for Subcellular Targeting and Interaction with l-Cysteine Desulfurase NFS1. | 9 |
Citation
Dessen P
ISCU (iron-sulfur cluster assembly enzyme)
Atlas Genet Cytogenet Oncol Haematol. 2014-06-01
Online version: http://atlasgeneticsoncology.org/gene/53990/iscu-(iron-sulfur-cluster-assembly-enzyme)
