ABCC3 (ATP binding cassette subfamily C member 3)

2003-08-01  

Identity

HGNC
ABCC3
LOCATION
17q21.33
LOCUSID
8714
ALIAS
ABC31,EST90757,MLP2,MOAT-D,MRP3,cMOAT2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8714
MIM: 604323
HGNC: 54
Ensembl: ENSG00000108846

Variants:

dbSNP: 8714
ClinVar: 8714
TCGA: ENSG00000108846
COSMIC: ABCC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108846ENST00000285238O15438
ENSG00000108846ENST00000427699O15438
ENSG00000108846ENST00000502426O15438
ENSG00000108846ENST00000505699O15438
ENSG00000108846ENST00000510633H0Y8T5
ENSG00000108846ENST00000513511D6RJE5
ENSG00000108846ENST00000513745H0Y8Q6
ENSG00000108846ENST00000515585H0Y9T4
ENSG00000108846ENST00000515707D6RAB7

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
ABC transportersKEGGko02010
ABC transportersKEGGhsa02010
Bile secretionKEGGko04976
Bile secretionKEGGhsa04976
Transmembrane transport of small moleculesREACTOMER-HSA-382551
ABC-family proteins mediated transportREACTOMER-HSA-382556
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Bile acid and bile salt metabolismREACTOMER-HSA-194068
Recycling of bile acids and saltsREACTOMER-HSA-159418
Antifolate resistanceKEGGko01523
Antifolate resistanceKEGGhsa01523

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA162263534OtotoxicityDiseaseClinicalAnnotationassociatedPD25141953, 27457817, 31666714
PA166169457tonsillectomyDiseaseVariantAnnotationassociatedPK
PA443937Drug ToxicityDiseaseClinicalAnnotationassociatedPD25141953, 27457817, 31666714
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD25141953, 27457817, 31666714
PA445208PainDiseaseClinicalAnnotationassociatedPK32090339
PA445522Respiratory InsufficiencyDiseaseVariantAnnotationassociatedPK
PA445601OsteosarcomaDiseaseClinicalAnnotationassociatedPD22016816
PA445687Sleep Apnea SyndromesDiseaseVariantAnnotationassociatedPK
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotationassociatedPKPD21606946
PA449014cisplatinChemicalClinicalAnnotationassociatedPD22016816, 25141953, 27457817, 31666714
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD22016816
PA449412doxorubicinChemicalClinicalAnnotationassociatedPD22016816
PA450163lamivudineChemicalPathwayassociated
PA450428methotrexateChemicalClinicalAnnotation, PathwayassociatedPKPD21317831, 21606946, 22016816
PA450550morphineChemicalClinicalAnnotation, VariantAnnotationassociatedPK32090339
PA451879vincristineChemicalClinicalAnnotation, PathwayassociatedPD22016816

References

Pubmed IDYearTitleCitations
385663042024Downregulation of ABCC3 activates MAPK signaling through accumulation of deoxycholic acid in colorectal cancer cells.1
386428452024SMARCA4 (BRG1) activates ABCC3 transcription to promote hepatocellular carcinogenesis.0
385663042024Downregulation of ABCC3 activates MAPK signaling through accumulation of deoxycholic acid in colorectal cancer cells.1
386428452024SMARCA4 (BRG1) activates ABCC3 transcription to promote hepatocellular carcinogenesis.0
353280662022Association Study of SLCO1B3 and ABCC3 Genetic Variants in Gallstone Disease.2
353280662022Association Study of SLCO1B3 and ABCC3 Genetic Variants in Gallstone Disease.2
335823212021Effect of bile acids on the expression of MRP3 and MRP4: An In vitro study in HepG2 cell line.5
338118422021CircABCC3 knockdown inhibits glioblastoma cell malignancy by regulating miR-770-5p/SOX2 axis through PI3K/AKT signaling pathway.8
350085102021The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes.7
335823212021Effect of bile acids on the expression of MRP3 and MRP4: An In vitro study in HepG2 cell line.5
338118422021CircABCC3 knockdown inhibits glioblastoma cell malignancy by regulating miR-770-5p/SOX2 axis through PI3K/AKT signaling pathway.8
350085102021The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes.7
322123302020Prevalence of ABCC3-1767G/A polymorphism among patients with antiretroviral-associated hepatotoxicity.3
322123302020Prevalence of ABCC3-1767G/A polymorphism among patients with antiretroviral-associated hepatotoxicity.3
294645512019Immunohistochemical Assessment of the Expression of Biliary Transportation Proteins MRP2 and MRP3 in Hepatocellular Carcinoma and in Cholangiocarcinoma.6

Citation

Dessen P

ABCC3 (ATP binding cassette subfamily C member 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/540/abcc3-(atp-binding-cassette-subfamily-c-member-3)