Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 123169
MIM: 610507
HGNC: 30401
Ensembl: ENSG00000166477
Variants:
dbSNP: 123169
ClinVar: 123169
TCGA: ENSG00000166477
COSMIC: LEO1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000166477 | ENST00000299601 | Q8WVC0 |
| ENSG00000166477 | ENST00000315141 | Q8WVC0 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37205756 | 2023 | CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation. | 3 |
| 38002344 | 2023 | LEO1 Is Required for Efficient Entry into Quiescence, Control of H3K9 Methylation and Gene Expression in Human Fibroblasts. | 0 |
| 37205756 | 2023 | CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation. | 3 |
| 38002344 | 2023 | LEO1 Is Required for Efficient Entry into Quiescence, Control of H3K9 Methylation and Gene Expression in Human Fibroblasts. | 0 |
| 34096589 | 2021 | LEO1 is a partner for Cockayne syndrome protein B (CSB) in response to transcription-blocking DNA damage. | 4 |
| 34096589 | 2021 | LEO1 is a partner for Cockayne syndrome protein B (CSB) in response to transcription-blocking DNA damage. | 4 |
| 30305722 | 2019 | Non-canonical activation of β-catenin by PRL-3 phosphatase in acute myeloid leukemia. | 11 |
| 30305722 | 2019 | Non-canonical activation of β-catenin by PRL-3 phosphatase in acute myeloid leukemia. | 11 |
| 24686170 | 2014 | LEO1 is regulated by PRL-3 and mediates its oncogenic properties in acute myelogenous leukemia. | 18 |
| 24686170 | 2014 | LEO1 is regulated by PRL-3 and mediates its oncogenic properties in acute myelogenous leukemia. | 18 |
| 24038468 | 2013 | Structural insights into Paf1 complex assembly and histone binding. | 35 |
| 24038468 | 2013 | Structural insights into Paf1 complex assembly and histone binding. | 35 |
| 20196086 | 2010 | Integrated genomic profiling identifies candidate genes implicated in glioma-genesis and a novel LEO1-SLC12A1 fusion gene. | 17 |
| 20196086 | 2010 | Integrated genomic profiling identifies candidate genes implicated in glioma-genesis and a novel LEO1-SLC12A1 fusion gene. | 17 |
Citation
Dessen P
LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component)
Atlas Genet Cytogenet Oncol Haematol. 2014-06-01
Online version: http://atlasgeneticsoncology.org/gene/54002/leo1-(leo1-homolog-paf1-rna-polymerase-ii-complex-component)
