LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component)

2014-06-01   Dessen P  

Identity

HGNC
LEO1
LOCATION
15q21.2
LOCUSID
123169
ALIAS
RDL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 123169
MIM: 610507
HGNC: 30401
Ensembl: ENSG00000166477

Variants:

dbSNP: 123169
ClinVar: 123169
TCGA: ENSG00000166477
COSMIC: LEO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166477ENST00000299601Q8WVC0
ENSG00000166477ENST00000315141Q8WVC0

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
Protein ubiquitinationREACTOMER-HSA-8852135
E3 ubiquitin ligases ubiquitinate target proteinsREACTOMER-HSA-8866654

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
372057562023CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation.3
380023442023LEO1 Is Required for Efficient Entry into Quiescence, Control of H3K9 Methylation and Gene Expression in Human Fibroblasts.0
372057562023CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation.3
380023442023LEO1 Is Required for Efficient Entry into Quiescence, Control of H3K9 Methylation and Gene Expression in Human Fibroblasts.0
340965892021LEO1 is a partner for Cockayne syndrome protein B (CSB) in response to transcription-blocking DNA damage.4
340965892021LEO1 is a partner for Cockayne syndrome protein B (CSB) in response to transcription-blocking DNA damage.4
303057222019Non-canonical activation of β-catenin by PRL-3 phosphatase in acute myeloid leukemia.11
303057222019Non-canonical activation of β-catenin by PRL-3 phosphatase in acute myeloid leukemia.11
246861702014LEO1 is regulated by PRL-3 and mediates its oncogenic properties in acute myelogenous leukemia.18
246861702014LEO1 is regulated by PRL-3 and mediates its oncogenic properties in acute myelogenous leukemia.18
240384682013Structural insights into Paf1 complex assembly and histone binding.35
240384682013Structural insights into Paf1 complex assembly and histone binding.35
201960862010Integrated genomic profiling identifies candidate genes implicated in glioma-genesis and a novel LEO1-SLC12A1 fusion gene.17
201960862010Integrated genomic profiling identifies candidate genes implicated in glioma-genesis and a novel LEO1-SLC12A1 fusion gene.17

Citation

Dessen P

LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/54002/leo1-(leo1-homolog-paf1-rna-polymerase-ii-complex-component)