KCNH7 (potassium voltage-gated channel subfamily H member 7)

2014-06-01  

Identity

HGNC
KCNH7
LOCATION
2q24.2
LOCUSID
90134
ALIAS
ERG3,HERG3,Kv11.3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 90134
MIM: 608169
HGNC: 18863
Ensembl: ENSG00000184611

Variants:

dbSNP: 90134
ClinVar: 90134
TCGA: ENSG00000184611
COSMIC: KCNH7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184611ENST00000328032Q9NS40
ENSG00000184611ENST00000332142Q9NS40
ENSG00000184611ENST00000618399A0A087WZQ1
ENSG00000184611ENST00000621889A0A087X077

Expression (GTEx)

0
1
2
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Voltage gated Potassium channelsREACTOMER-HSA-1296072

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
358182232022Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome.0
358182232022Potassium Ion Channel Protein (KCNH) Levels in Patients with Fibromyalgia Syndrome.0
327238622020Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel.13
327238622020Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel.13
300165512018ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice.6
300165512018ERG3 potassium channel-mediated suppression of neuronal intrinsic excitability and prevention of seizure generation in mice.6
269428842016Activation of hERG3 channel stimulates autophagy and promotes cellular senescence in melanoma.22
269428842016Activation of hERG3 channel stimulates autophagy and promotes cellular senescence in melanoma.22
249869162014A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder.27
249869162014A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder.27
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
191561662009IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients.6

Citation

Dessen P

KCNH7 (potassium voltage-gated channel subfamily H member 7)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/54005/kcnh7-(potassium-voltage-gated-channel-subfamily-h-member-7)