Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23621
MIM: 604252
HGNC: 933
Ensembl: ENSG00000186318
Variants:
dbSNP: 23621
ClinVar: 23621
TCGA: ENSG00000186318
COSMIC: BACE1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Alzheimer's disease | KEGG | ko05010 |
| Alzheimer's disease | KEGG | hsa05010 |
| Metabolism of proteins | REACTOME | R-HSA-392499 |
| Amyloid fiber formation | REACTOME | R-HSA-977225 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38227464 | 2024 | Determining Structural Changes for Ligand Recognition between Human and Rat Phosphorylated BACE1 in Silico and Its Phosphorylation by GSK3β at Thr252 by in Vitro Studies. | 0 |
| 38227464 | 2024 | Determining Structural Changes for Ligand Recognition between Human and Rat Phosphorylated BACE1 in Silico and Its Phosphorylation by GSK3β at Thr252 by in Vitro Studies. | 0 |
| 36847009 | 2023 | Bilateral Hippocampal Volume Mediated the Relationship Between Plasma BACE1 Concentration and Memory Function in the Early Stage of Alzheimer's Disease: A Cross-Sectional Study. | 0 |
| 37085111 | 2023 | TNIP2 inhibits amyloidogenesis by regulating the 3'UTR of BACE1: An in vitro study. | 0 |
| 37175873 | 2023 | β-Secretase-1: In Silico Drug Reposition for Alzheimer's Disease. | 2 |
| 37286480 | 2023 | BACE1 SUMOylation deregulates phosphorylation and ubiquitination in Alzheimer's disease pathology. | 2 |
| 37355492 | 2023 | APP-BACE1 Interaction and Intracellular Localization Regulate Aβ Production in iPSC-Derived Cortical Neurons. | 3 |
| 37552127 | 2023 | Inhibition of BACE1 attenuates microglia-induced neuroinflammation after intracerebral hemorrhage by suppressing STAT3 activation. | 0 |
| 37658602 | 2023 | Characterizing the transmembrane domains of ADAM10 and BACE1 and the impact of membrane composition. | 0 |
| 37986103 | 2023 | m6A modified BACE1-AS contributes to liver metastasis and stemness-like properties in colorectal cancer through TUFT1 dependent activation of Wnt signaling. | 2 |
| 36847009 | 2023 | Bilateral Hippocampal Volume Mediated the Relationship Between Plasma BACE1 Concentration and Memory Function in the Early Stage of Alzheimer's Disease: A Cross-Sectional Study. | 0 |
| 37085111 | 2023 | TNIP2 inhibits amyloidogenesis by regulating the 3'UTR of BACE1: An in vitro study. | 0 |
| 37175873 | 2023 | β-Secretase-1: In Silico Drug Reposition for Alzheimer's Disease. | 2 |
| 37286480 | 2023 | BACE1 SUMOylation deregulates phosphorylation and ubiquitination in Alzheimer's disease pathology. | 2 |
| 37355492 | 2023 | APP-BACE1 Interaction and Intracellular Localization Regulate Aβ Production in iPSC-Derived Cortical Neurons. | 3 |
Citation
Dessen P
BACE1 (beta-secretase 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-06-01
Online version: http://atlasgeneticsoncology.org/gene/54008/bace1-(beta-secretase-1)
