TEAD4 (TEA domain transcription factor 4)

2014-06-01  

Identity

HGNC
TEAD4
LOCATION
12p13.33
LOCUSID
7004
ALIAS
EFTR-2,RTEF1,TCF13L1,TEF-3,TEF3,TEFR-1,hRTEF-1B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7004
MIM: 601714
HGNC: 11717
Ensembl: ENSG00000197905

Variants:

dbSNP: 7004
ClinVar: 7004
TCGA: ENSG00000197905
COSMIC: TEAD4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197905ENST00000358409A0A0A0MRF3
ENSG00000197905ENST00000359864Q53GI4
ENSG00000197905ENST00000397122Q15561
ENSG00000197905ENST00000443986H0Y7B0
ENSG00000197905ENST00000536826H0YFF9
ENSG00000197905ENST00000540314H0YFK0
ENSG00000197905ENST00000543035H0YGS2
ENSG00000197905ENST00000544666H0YG62

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Hippo signalingKEGGhsa_M00683
Hippo signalingKEGGM00683
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
YAP1- and WWTR1 (TAZ)-stimulated gene expressionREACTOMER-HSA-2032785
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380722842024TEAD4: A key regulator of tumor metastasis and chemoresistance - Mechanisms and therapeutic implications.1
382333812024VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification.2
383969002024Integrative Epigenetic and Molecular Analysis Reveals a Novel Promoter for a New Isoform of the Transcription Factor TEAD4.0
385225132024The tumor suppressor NF2 modulates TEAD4 stability and activity in Hippo signaling via direct interaction.0
387896842024Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification.0
380722842024TEAD4: A key regulator of tumor metastasis and chemoresistance - Mechanisms and therapeutic implications.1
382333812024VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification.2
383969002024Integrative Epigenetic and Molecular Analysis Reveals a Novel Promoter for a New Isoform of the Transcription Factor TEAD4.0
385225132024The tumor suppressor NF2 modulates TEAD4 stability and activity in Hippo signaling via direct interaction.0
387896842024Tead4 and Tfap2c generate bipotency and a bistable switch in totipotent embryos to promote robust lineage diversification.0
365999722023MAD2L1 is transcriptionally regulated by TEAD4 and promotes cell proliferation and migration in colorectal cancer.1
367811222023The YAP-TEAD4 complex promotes tumor lymphangiogenesis by transcriptionally upregulating CCBE1 in colorectal cancer.3
368068552023Tea domain transcription factor TEAD4 mitigates TGF-β signaling and hepatocellular carcinoma progression independently of YAP.4
371518792023Bulk and single-cell transcriptome profiling reveal extracellular matrix mechanical regulation of lipid metabolism reprograming through YAP/TEAD4/ACADL axis in hepatocellular carcinoma.9
371695702023TFAP2C exacerbates psoriasis-like inflammation by promoting Th17 and Th1 cells activation through regulating TEAD4 transcription.2

Citation

Dessen P

TEAD4 (TEA domain transcription factor 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/54031/tead4-(tea-domain-transcription-factor-4)