Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 25821
MIM: 614667
HGNC: 19261
Ensembl: ENSG00000135297
Variants:
dbSNP: 25821
ClinVar: 25821
TCGA: ENSG00000135297
COSMIC: MTO1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| tRNA processing | REACTOME | R-HSA-72306 |
| tRNA modification in the mitochondrion | REACTOME | R-HSA-6787450 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34990597 | 2022 | Clinical and genetic analysis of combined oxidative phosphorylation defificiency-10 caused by MTO1 mutation. | 3 |
| 34990597 | 2022 | Clinical and genetic analysis of combined oxidative phosphorylation defificiency-10 caused by MTO1 mutation. | 3 |
| 34238206 | 2021 | CircMTO1 inhibits ox-LDL-stimulated vascular smooth muscle cell proliferation and migration via regulating the miR-182-5p/RASA1 axis. | 7 |
| 34930906 | 2021 | CircMTO1 suppresses hepatocellular carcinoma progression via the miR-541-5p/ZIC1 axis by regulating Wnt/β-catenin signaling pathway and epithelial-to-mesenchymal transition. | 21 |
| 34238206 | 2021 | CircMTO1 inhibits ox-LDL-stimulated vascular smooth muscle cell proliferation and migration via regulating the miR-182-5p/RASA1 axis. | 7 |
| 34930906 | 2021 | CircMTO1 suppresses hepatocellular carcinoma progression via the miR-541-5p/ZIC1 axis by regulating Wnt/β-catenin signaling pathway and epithelial-to-mesenchymal transition. | 21 |
| 31842146 | 2020 | Novel Mitochondrial Translation Optimizer-1 Mutations as a Cause of Hereditary Optic Neuropathy. | 2 |
| 32731816 | 2020 | Circular RNA MTO1 Inhibits the Proliferation and Invasion of Ovarian Cancer Cells Through the miR-182-5p/KLF15 Axis. | 13 |
| 31842146 | 2020 | Novel Mitochondrial Translation Optimizer-1 Mutations as a Cause of Hereditary Optic Neuropathy. | 2 |
| 32731816 | 2020 | Circular RNA MTO1 Inhibits the Proliferation and Invasion of Ovarian Cancer Cells Through the miR-182-5p/KLF15 Axis. | 13 |
| 31148365 | 2019 | CircMTO1 inhibits liver fibrosis via regulation of miR-17-5p and Smad7. | 28 |
| 31148365 | 2019 | CircMTO1 inhibits liver fibrosis via regulation of miR-17-5p and Smad7. | 28 |
| 29331171 | 2018 | The genotypic and phenotypic spectrum of MTO1 deficiency. | 9 |
| 29348686 | 2018 | Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARγ-UCP2-AMPK axis. | 14 |
| 29440775 | 2018 | Genetic defects in mtDNA-encoded protein translation cause pediatric, mitochondrial cardiomyopathy with early-onset brain disease. | 14 |
Citation
Dessen P
MTO1 (mitochondrial tRNA translation optimization 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-07-01
Online version: http://atlasgeneticsoncology.org/gene/54043/mto1-(mitochondrial-trna-translation-optimization-1)
