GPRC5D (G protein-coupled receptor class C group 5 member D)

2014-07-01  

Identity

HGNC
GPRC5D
LOCATION
12p13.1
LOCUSID
55507
ALIAS
-

Other Information

Locus ID:

NCBI: 55507
MIM: 607437
HGNC: 13310
Ensembl: ENSG00000111291

Variants:

dbSNP: 55507
ClinVar: 55507
TCGA: ENSG00000111291
COSMIC: GPRC5D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111291ENST00000228887Q9NZD1
ENSG00000111291ENST00000396333Q9NZD1
ENSG00000111291ENST00000541128F5GWX9

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383078652024GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review.4
383078652024GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review.4
375745512023GPRC5D as a promising therapeutic target in EGFR-wild and immuno-cold non-small cell lung cancer.0
376531402023Acquired resistance to a GPRC5D-directed T-cell engager in multiple myeloma is mediated by genetic or epigenetic target inactivation.9
378199612023Genetic Basis of Relapse after GPRC5D-Targeted CAR T Cells.2
375745512023GPRC5D as a promising therapeutic target in EGFR-wild and immuno-cold non-small cell lung cancer.0
376531402023Acquired resistance to a GPRC5D-directed T-cell engager in multiple myeloma is mediated by genetic or epigenetic target inactivation.9
378199612023Genetic Basis of Relapse after GPRC5D-Targeted CAR T Cells.2
235105262013GPRC5D is a promising marker for monitoring the tumor load and to target multiple myeloma cells.20
235105262013GPRC5D is a promising marker for monitoring the tumor load and to target multiple myeloma cells.20
225910132012Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma.49
225910132012Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma.49
204244732010L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.0
204244732010L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.0

Citation

Dessen P

GPRC5D (G protein-coupled receptor class C group 5 member D)

Atlas Genet Cytogenet Oncol Haematol. 2014-07-01

Online version: http://atlasgeneticsoncology.org/gene/54079/gprc5d-(g-protein-coupled-receptor-class-c-group-5-member-d)