AHCTF1 (AT-hook containing transcription factor 1)

2014-08-01  

Identity

HGNC
LOCATION
1q44
LOCUSID
ALIAS
ELYS,MST108,MSTP108,TMBS62
FUSION GENES

Other Information

Locus ID:

NCBI: 25909
MIM: 610853
HGNC: 24618
Ensembl: ENSG00000153207

Variants:

dbSNP: 25909
ClinVar: 25909
TCGA: ENSG00000153207
COSMIC: AHCTF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153207ENST00000326225Q8WYP5
ENSG00000153207ENST00000366508Q8WYP5
ENSG00000153207ENST00000498601H7C4S1
ENSG00000153207ENST00000648844Q8WYP5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
386052782024Phosphorylation of ELYS promotes its interaction with VAPB at decondensing chromosomes during mitosis.1
386052782024Phosphorylation of ELYS promotes its interaction with VAPB at decondensing chromosomes during mitosis.1
350175272022Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site.9
350175272022Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site.9
310856252019The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity.33
317847292019WNT signaling and AHCTF1 promote oncogenic MYC expression through super-enhancer-mediated gene gating.38
310856252019The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity.33
317847292019WNT signaling and AHCTF1 promote oncogenic MYC expression through super-enhancer-mediated gene gating.38
278021612016ELYS regulates the localization of LBR by modulating its phosphorylation state.16
278021612016ELYS regulates the localization of LBR by modulating its phosphorylation state.16
225556032012The nucleoporin ELYS/Mel28 regulates nuclear envelope subdomain formation in HeLa cells.32
225556032012The nucleoporin ELYS/Mel28 regulates nuclear envelope subdomain formation in HeLa cells.32
170988632006ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division.152
170988632006ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division.152

Citation

Dessen P

AHCTF1 (AT-hook containing transcription factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54112/ahctf1-(at-hook-containing-transcription-factor-1)