APOO (apolipoprotein O)

2014-08-01  

Identity

HGNC
LOCATION
Xp22.11
LOCUSID
ALIAS
FAM121B,MIC26,MICOS26,Mic23,My025
FUSION GENES

Other Information

Locus ID:

NCBI: 79135
MIM: 300753
HGNC: 28727
Ensembl: ENSG00000184831

Variants:

dbSNP: 79135
ClinVar: 79135
TCGA: ENSG00000184831
COSMIC: APOO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184831ENST00000379226Q9BUR5
ENSG00000184831ENST00000439528H7C1U8
ENSG00000184831ENST00000490078G3V1B6
ENSG00000184831ENST00000633372A0A0J9YXS4
ENSG00000184831ENST00000633432A0A0J9YXT7
ENSG00000184831ENST00000634086A0A0J9YWW6

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
192047262009Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.63
208773002012Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project.26
169568922006ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart.20
247431512014Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart.17
257649792015The non-glycosylated isoform of MIC26 is a constituent of the mammalian MICOS complex and promotes formation of crista junctions.16
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
300922692018Loss of MICOS complex integrity and mitochondrial damage, but not TDP-43 mitochondrial localisation, are likely associated with severity of CHCHD10-related diseases.10
243417432013Microarray analysis provides new insights into the function of apolipoprotein O in HepG2 cell line.4
226932552012Plasma apolipoprotein O level increased in the patients with acute coronary syndrome.3

Citation

Dessen P

APOO (apolipoprotein O)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54131/apoo-(apolipoprotein-o)