ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2)

2014-08-01  

Identity

HGNC
ARIH2
LOCATION
3p21.31
LOCUSID
10425
ALIAS
ARI2,TRIAD1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10425
MIM: 605615
HGNC: 690
Ensembl: ENSG00000177479

Variants:

dbSNP: 10425
ClinVar: 10425
TCGA: ENSG00000177479
COSMIC: ARIH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177479ENST00000356401O95376
ENSG00000177479ENST00000356401Q6IBL8
ENSG00000177479ENST00000420814C9JBC5
ENSG00000177479ENST00000430423C9JZ71
ENSG00000177479ENST00000433170C9JAU2
ENSG00000177479ENST00000449376O95376
ENSG00000177479ENST00000449376Q6IBL8
ENSG00000177479ENST00000449729C9JCL4
ENSG00000177479ENST00000452385F8WCS4
ENSG00000177479ENST00000452882C9JBC5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
357326172022ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.5
357326172022ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.5
305875762019Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling.10
312535902019ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.31
305875762019Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling.10
312535902019ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.31
294597122018The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia.12
294597122018The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia.12
290213762017ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.62
290213762017ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.62
244863252014A novel feed-forward loop between ARIH2 E3-ligase and PABPN1 regulates aging-associated muscle degeneration.14
244863252014A novel feed-forward loop between ARIH2 E3-ligase and PABPN1 regulates aging-associated muscle degeneration.14
240766552013TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.61
240766552013TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.61
220374232012Differential regulation of PML-RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.9

Citation

Dessen P

ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54134/arih2-(ariadne-rbr-e3-ubiquitin-protein-ligase-2)