ATG16L2 (autophagy related 16 like 2)

2014-08-01 Affiliation

Identity

HGNC

ATG16L2

LOCATION

11q13.4

LOCUSID

89849

ALIAS

ATG16B,WDR80

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 89849
MIM: 618716
HGNC: 25464
Ensembl: ENSG00000168010

Variants:

dbSNP: 89849
ClinVar: 89849
TCGA: ENSG00000168010
COSMIC: ATG16L2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000168010	ENST00000321297	Q8NAA4
ENSG00000168010	ENST00000435507	F5GWM4
ENSG00000168010	ENST00000534905	F5GWZ9
ENSG00000168010	ENST00000535830	H0YFG0
ENSG00000168010	ENST00000537837	H0YFC3
ENSG00000168010	ENST00000538973	H0YG67
ENSG00000168010	ENST00000540222	H0YG45
ENSG00000168010	ENST00000540567	H0YGJ8
ENSG00000168010	ENST00000541367	H0YF72
ENSG00000168010	ENST00000541554	H0YFZ7
ENSG00000168010	ENST00000541999	H0YGE3
ENSG00000168010	ENST00000544490	F5H7B6

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Autophagy - animal	KEGG	ko04140
Autophagy - animal	KEGG	hsa04140

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35239457	2022	The role of ATG16L2 in autophagy and disease.	11
35239457	2022	The role of ATG16L2 in autophagy and disease.	11
33113339	2021	Identification of a novel differentially methylated region adjacent to ATG16L2 in lung cancer cells using methyl-CpG binding domain protein-enriched genome sequencing.	3
33113339	2021	Identification of a novel differentially methylated region adjacent to ATG16L2 in lung cancer cells using methyl-CpG binding domain protein-enriched genome sequencing.	3
31692259	2019	Potentially functional variants of autophagy-related genes are associated with the efficacy and toxicity of radiotherapy in patients with nasopharyngeal carcinoma.	14
31692259	2019	Potentially functional variants of autophagy-related genes are associated with the efficacy and toxicity of radiotherapy in patients with nasopharyngeal carcinoma.	14
29454863	2018	Potentially Functional Variants of ATG16L2 Predict Radiation Pneumonitis and Outcomes in Patients with Non-Small Cell Lung Cancer after Definitive Radiotherapy.	24
29454863	2018	Potentially Functional Variants of ATG16L2 Predict Radiation Pneumonitis and Outcomes in Patients with Non-Small Cell Lung Cancer after Definitive Radiotherapy.	24
26663301	2016	Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.	39
27611316	2016	A functional variant of ATG16L2 is associated with Crohn's disease in the Chinese population.	6
26663301	2016	Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.	39
27611316	2016	A functional variant of ATG16L2 is associated with Crohn's disease in the Chinese population.	6
23850713	2014	Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.	76
24406150	2014	Autophagy-related gene16L2, a potential serum biomarker of multiple sclerosis evaluated by bead-based proteomic technology.	20
23850713	2014	Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.	76

Citation

Dessen P

ATG16L2 (autophagy related 16 like 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54138/atg16l2-(autophagy-related-16-like-2)