BICD1 (BICD cargo adaptor 1)

2014-08-01  

Identity

HGNC
BICD1
LOCATION
12p11.21
LOCUSID
636
ALIAS
BICD,bic-D
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 636
MIM: 602204
HGNC: 1049
Ensembl: ENSG00000151746

Variants:

dbSNP: 636
ClinVar: 636
TCGA: ENSG00000151746
COSMIC: BICD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151746ENST00000395758A8MVZ6
ENSG00000151746ENST00000547680U3KQF7
ENSG00000151746ENST00000548411Q96G01
ENSG00000151746ENST00000550207F8VZX7
ENSG00000151746ENST00000551086F8W056
ENSG00000151746ENST00000551848Q96G01
ENSG00000151746ENST00000552160A0A087WYJ7
ENSG00000151746ENST00000652176Q96G01

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-independent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811436

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
207098202011Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema.55
207098202011Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema.55
206866082010Genome-wide association study of pancreatic cancer in Japanese population.53
200806502010Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.46
171392492006GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.39
184872432008A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans.33
171016442007The Rab6 effector Bicaudal D1 associates with Chlamydia trachomatis inclusions in a biovar-specific manner.25
177073692007A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells.23
163208332005BicD-dependent localization processes: from Drosophilia development to human cell biology.18

Citation

Dessen P

BICD1 (BICD cargo adaptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54156/bicd1-(bicd-cargo-adaptor-1)