CCP110 (centriolar coiled-coil protein 110)

2014-08-01  

Identity

HGNC
LOCATION
16p12.3
LOCUSID
ALIAS
CP110,Cep110
FUSION GENES

Other Information

Locus ID:

NCBI: 9738
MIM: 609544
HGNC: 24342
Ensembl: ENSG00000103540

Variants:

dbSNP: 9738
ClinVar: 9738
TCGA: ENSG00000103540
COSMIC: CCP110

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103540ENST00000381396O43303
ENSG00000103540ENST00000396208O43303
ENSG00000103540ENST00000396212O43303
ENSG00000103540ENST00000561888I3L262
ENSG00000103540ENST00000562083H3BVH3
ENSG00000103540ENST00000565376H3BMS1

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
384157882024Emerging insights into CP110 removal during early steps of ciliogenesis.0
384157882024Emerging insights into CP110 removal during early steps of ciliogenesis.0
370749242023EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole.7
372262382023CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis.3
370749242023EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole.7
372262382023CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis.3
348136482022LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.9
348136482022LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.9
327471922021Primary cilia biogenesis and associated retinal ciliopathies.41
334916012021Myeloid/lymphoid neoplasm with CEP110-FGFR1 fusion: An analysis of 16 cases show common features and poor prognosis.5
342596272021CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels.20
327471922021Primary cilia biogenesis and associated retinal ciliopathies.41
334916012021Myeloid/lymphoid neoplasm with CEP110-FGFR1 fusion: An analysis of 16 cases show common features and poor prognosis.5
342596272021CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels.20
282427912017Response to Tyrosine Kinase Inhibitors in Myeloproliferative Neoplasia with 8p11 Translocation and CEP110-FGFR1 Rearrangement.4

Citation

Dessen P

CCP110 (centriolar coiled-coil protein 110)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54205/ccp110-(centriolar-coiled-coil-protein-110)