Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 54901
MIM: 611259
HGNC: 21050
Ensembl: ENSG00000145996
Variants:
dbSNP: 54901
ClinVar: 54901
TCGA: ENSG00000145996
COSMIC: CDKAL1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000145996 | ENST00000274695 | Q5VV42 |
| ENSG00000145996 | ENST00000378610 | Q5VV42 |
| ENSG00000145996 | ENST00000613575 | Q5VV42 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Gene Expression | REACTOME | R-HSA-74160 |
| tRNA processing | REACTOME | R-HSA-72306 |
| tRNA modification in the nucleus and cytosol | REACTOME | R-HSA-6782315 |
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164712689 | Dipeptidyl peptidase 4 (DPP-4) inhibitors | Chemical | ClinicalAnnotation | associated | PD | ||
| PA164713366 | Tumor necrosis factor alpha (TNF-alpha) inhibitors | Chemical | ClinicalAnnotation | associated | PD | 27670765 | |
| PA443886 | Diabetes Mellitus | Disease | ClinicalAnnotation, MultilinkAnnotation | associated | PD | 27139004 | |
| PA445451 | Psoriasis | Disease | ClinicalAnnotation | associated | PD | 27670765 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38237400 | 2024 | CDC123 promotes Hepatocellular Carcinoma malignant progression by regulating CDKAL1. | 0 |
| 38237400 | 2024 | CDC123 promotes Hepatocellular Carcinoma malignant progression by regulating CDKAL1. | 0 |
| 33269568 | 2023 | The triglyceride glucose index and CDKAL1 gene rs10946398 SNP are associated with NAFLD in Chinese adults. | 3 |
| 33641658 | 2023 | TCF7L2 (rs7903146) But Not CDKAL1 (rs7754840) Gene Polymorphisms Increase the Risk of New-Onset Diabetes After Kidney Transplant. | 1 |
| 36301463 | 2023 | Association of CDKAL1 gene polymorphism (rs10946398) with gestational diabetes mellitus in Pakistani population. | 1 |
| 36628934 | 2023 | FTO demethylates m6A modifications in CDKAL1 mRNA and promotes gastric cancer chemoresistance by altering mitochondrial dynamics. | 0 |
| 36786012 | 2023 | CDKAL1 Drives the Maintenance of Cancer Stem-Like Cells by Assembling the eIF4F Translation Initiation Complex. | 3 |
| 37055162 | 2023 | Association of the CDKAL1 gene polymorphism with gestational diabetes mellitus in Chinese women. | 2 |
| 37245423 | 2023 | Hepatic Cdkal1 deletion regulates HDL catabolism and promotes reverse cholesterol transport. | 0 |
| 37308106 | 2023 | Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations. | 4 |
| 37628646 | 2023 | The Association between CDKAL1 Gene rs10946398 Polymorphism and Post-Transplant Diabetes in Kidney Allograft Recipients Treated with Tacrolimus. | 0 |
| 33269568 | 2023 | The triglyceride glucose index and CDKAL1 gene rs10946398 SNP are associated with NAFLD in Chinese adults. | 3 |
| 33641658 | 2023 | TCF7L2 (rs7903146) But Not CDKAL1 (rs7754840) Gene Polymorphisms Increase the Risk of New-Onset Diabetes After Kidney Transplant. | 1 |
| 36301463 | 2023 | Association of CDKAL1 gene polymorphism (rs10946398) with gestational diabetes mellitus in Pakistani population. | 1 |
| 36628934 | 2023 | FTO demethylates m6A modifications in CDKAL1 mRNA and promotes gastric cancer chemoresistance by altering mitochondrial dynamics. | 0 |
Citation
Dessen P
CDKAL1 (CDK5 regulatory subunit associated protein 1 like 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54207/cdkal1-(cdk5-regulatory-subunit-associated-protein-1-like-1)
