CDKAL1 (CDK5 regulatory subunit associated protein 1 like 1)

2014-08-01  

Identity

HGNC
CDKAL1
LOCATION
6p22.3
LOCUSID
54901
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54901
MIM: 611259
HGNC: 21050
Ensembl: ENSG00000145996

Variants:

dbSNP: 54901
ClinVar: 54901
TCGA: ENSG00000145996
COSMIC: CDKAL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145996ENST00000274695Q5VV42
ENSG00000145996ENST00000378610Q5VV42
ENSG00000145996ENST00000613575Q5VV42

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
tRNA processingREACTOMER-HSA-72306
tRNA modification in the nucleus and cytosolREACTOMER-HSA-6782315

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164712689Dipeptidyl peptidase 4 (DPP-4) inhibitorsChemicalClinicalAnnotationassociatedPD
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD27670765
PA443886Diabetes MellitusDiseaseClinicalAnnotation, MultilinkAnnotationassociatedPD27139004
PA445451PsoriasisDiseaseClinicalAnnotationassociatedPD27670765

References

Pubmed IDYearTitleCitations
382374002024CDC123 promotes Hepatocellular Carcinoma malignant progression by regulating CDKAL1.0
382374002024CDC123 promotes Hepatocellular Carcinoma malignant progression by regulating CDKAL1.0
332695682023The triglyceride glucose index and CDKAL1 gene rs10946398 SNP are associated with NAFLD in Chinese adults.3
336416582023TCF7L2 (rs7903146) But Not CDKAL1 (rs7754840) Gene Polymorphisms Increase the Risk of New-Onset Diabetes After Kidney Transplant.1
363014632023Association of CDKAL1 gene polymorphism (rs10946398) with gestational diabetes mellitus in Pakistani population.1
366289342023FTO demethylates m6A modifications in CDKAL1 mRNA and promotes gastric cancer chemoresistance by altering mitochondrial dynamics.0
367860122023CDKAL1 Drives the Maintenance of Cancer Stem-Like Cells by Assembling the eIF4F Translation Initiation Complex.3
370551622023Association of the CDKAL1 gene polymorphism with gestational diabetes mellitus in Chinese women.2
372454232023Hepatic Cdkal1 deletion regulates HDL catabolism and promotes reverse cholesterol transport.0
373081062023Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations.4
376286462023The Association between CDKAL1 Gene rs10946398 Polymorphism and Post-Transplant Diabetes in Kidney Allograft Recipients Treated with Tacrolimus.0
332695682023The triglyceride glucose index and CDKAL1 gene rs10946398 SNP are associated with NAFLD in Chinese adults.3
336416582023TCF7L2 (rs7903146) But Not CDKAL1 (rs7754840) Gene Polymorphisms Increase the Risk of New-Onset Diabetes After Kidney Transplant.1
363014632023Association of CDKAL1 gene polymorphism (rs10946398) with gestational diabetes mellitus in Pakistani population.1
366289342023FTO demethylates m6A modifications in CDKAL1 mRNA and promotes gastric cancer chemoresistance by altering mitochondrial dynamics.0

Citation

Dessen P

CDKAL1 (CDK5 regulatory subunit associated protein 1 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54207/cdkal1-(cdk5-regulatory-subunit-associated-protein-1-like-1)