CENPT (centromere protein T)

2014-08-01  

Identity

HGNC
CENPT
LOCATION
16q22.1
LOCUSID
80152
ALIAS
C16orf56,CENP-T,SSMGA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80152
MIM: 611510
HGNC: 25787
Ensembl: ENSG00000102901

Variants:

dbSNP: 80152
ClinVar: 80152
TCGA: ENSG00000102901
COSMIC: CENPT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102901ENST00000440851Q96BT3
ENSG00000102901ENST00000561593H3BMP6
ENSG00000102901ENST00000562338H3BQJ0
ENSG00000102901ENST00000562462H3BQS6
ENSG00000102901ENST00000562513I3L4F8
ENSG00000102901ENST00000562787Q96BT3
ENSG00000102901ENST00000564817H3BTR4
ENSG00000102901ENST00000565114H3BQ71
ENSG00000102901ENST00000565713H3BTS2
ENSG00000102901ENST00000566067H3BN05
ENSG00000102901ENST00000566758H3BUW2
ENSG00000102901ENST00000568069H3BQS6
ENSG00000102901ENST00000626059H3BQS6

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
190705752008CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore.166
225613462012CENP-T proteins are conserved centromere receptors of the Ndc80 complex.80
233342972013CENP-T provides a structural platform for outer kinetochore assembly.75
256605452015Distinct organization and regulation of the outer kinetochore KMN network downstream of CENP-C and CENP-T.39
216951102011Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state.32
258437102015HJURP involvement in de novo CenH3(CENP-A) and CENP-C recruitment.32
280122762016Molecular basis of outer kinetochore assembly on CENP-T.30
281677792017Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T.24
272841632016The CENP-T/-W complex is a binding partner of the histone chaperone FACT.15
194129742008Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B.14

Citation

Dessen P

CENPT (centromere protein T)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54209/cenpt-(centromere-protein-t)