CHID1 (chitinase domain containing 1)

2014-08-01  

Identity

HGNC
LOCATION
11p15.5
LOCUSID
ALIAS
GL008,SI-CLP,SICLP
FUSION GENES

Other Information

Locus ID:

NCBI: 66005
MIM: 615692
HGNC: 28474
Ensembl: ENSG00000177830

Variants:

dbSNP: 66005
ClinVar: 66005
TCGA: ENSG00000177830
COSMIC: CHID1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177830ENST00000323578Q9BWS9
ENSG00000177830ENST00000429789Q9BWS9
ENSG00000177830ENST00000436108Q9BWS9
ENSG00000177830ENST00000449825Q9BWS9
ENSG00000177830ENST00000454838Q9BWS9
ENSG00000177830ENST00000525225E9PKF1
ENSG00000177830ENST00000525840E9PJ91
ENSG00000177830ENST00000528154E9PJL0
ENSG00000177830ENST00000528426E9PQZ0
ENSG00000177830ENST00000528521H0YEA3
ENSG00000177830ENST00000528581Q9BWS9
ENSG00000177830ENST00000529539H0YC89
ENSG00000177830ENST00000530939E9PI70
ENSG00000177830ENST00000531859E9PPA0
ENSG00000177830ENST00000532909H0YDL6
ENSG00000177830ENST00000533056E9PRL3
ENSG00000177830ENST00000533059E9PIP0
ENSG00000177830ENST00000534207H0YCC4
ENSG00000177830ENST00000534254E9PPH0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
267331602016Role of chitinase-like proteins in cancer.17
207244792010Structure of human stabilin-1 interacting chitinase-like protein (SI-CLP) reveals a saccharide-binding cleft with lower sugar-binding selectivity.15
244703462014Human secreted stabilin-1-interacting chitinase-like protein aggravates the inflammation associated with rheumatoid arthritis and is a potential macrophage inflammatory regulator in rodents.5
192757512009Crystallization and preliminary X-ray crystallographic studies on SI-CLP, a novel human Glyco_18 domain-containing protein.1
311068672019CHID1 positively regulates RLR antiviral signaling by targeting the RIG-I/VISA signalosome.0

Citation

Dessen P

CHID1 (chitinase domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54216/chid1-(chitinase-domain-containing-1)