Identity
HGNC
LOCATION
1q25.1
LOCUSID
ALIAS
ASPRS,LBSL,MT-ASPRS,mtAspRS
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55157
MIM: 610956
HGNC: 25538
Ensembl: ENSG00000117593
Variants:
dbSNP: 55157
ClinVar: 55157
TCGA: ENSG00000117593
COSMIC: DARS2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38382106 | 2024 | Functional enrichment analysis reveals the involvement of DARS2 in multiple biological pathways and its potential as a therapeutic target in esophageal carcinoma. | 0 |
| 38790244 | 2024 | Identification of a Novel Indel Variant in the DARS2 Gene in Russian Patients with Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation. | 0 |
| 38382106 | 2024 | Functional enrichment analysis reveals the involvement of DARS2 in multiple biological pathways and its potential as a therapeutic target in esophageal carcinoma. | 0 |
| 38790244 | 2024 | Identification of a Novel Indel Variant in the DARS2 Gene in Russian Patients with Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation. | 0 |
| 37563224 | 2023 | Mutations in DARS2 result in global dysregulation of mRNA metabolism and splicing. | 1 |
| 37626419 | 2023 | DARS2 overexpression is associated with PET/CT metabolic parameters and affects glycolytic activity in lung adenocarcinoma. | 4 |
| 37950542 | 2023 | DARS2 promotes the occurrence of lung adenocarcinoma via the ERK/c-Myc signaling pathway. | 2 |
| 37563224 | 2023 | Mutations in DARS2 result in global dysregulation of mRNA metabolism and splicing. | 1 |
| 37626419 | 2023 | DARS2 overexpression is associated with PET/CT metabolic parameters and affects glycolytic activity in lung adenocarcinoma. | 4 |
| 37950542 | 2023 | DARS2 promotes the occurrence of lung adenocarcinoma via the ERK/c-Myc signaling pathway. | 2 |
| 36085578 | 2022 | High expression of DARS2 indicates poor prognosis in lung adenocarcinoma. | 7 |
| 36085578 | 2022 | High expression of DARS2 indicates poor prognosis in lung adenocarcinoma. | 7 |
| 33972171 | 2021 | Phenotypic diversity of brain MRI patterns in mitochondrial aminoacyl-tRNA synthetase mutations. | 12 |
| 33972171 | 2021 | Phenotypic diversity of brain MRI patterns in mitochondrial aminoacyl-tRNA synthetase mutations. | 12 |
| 32766765 | 2020 | DARS2 is indispensable for Purkinje cell survival and protects against cerebellar ataxia. | 10 |
Citation
Dessen P
DARS2 (aspartyl-tRNA synthetase 2, mitochondrial)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54247/dars2-(aspartyl-trna-synthetase-2-mitochondrial)
