DDI2 (DNA damage inducible 1 homolog 2)

2014-08-01  

Identity

HGNC
DDI2
LOCATION
1p36.21
LOCUSID
84301
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84301
HGNC: 24578
Ensembl: ENSG00000197312

Variants:

dbSNP: 84301
ClinVar: 84301
TCGA: ENSG00000197312
COSMIC: DDI2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197312ENST00000320153H0YII4
ENSG00000197312ENST00000480945Q5TDH0
ENSG00000197312ENST00000483899H0YI90

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370848172023UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage.1
370848172023UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage.1
346492782022Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival.12
355896862022The aspartyl protease DDI2 drives adaptation to proteasome inhibition in multiple myeloma.7
346492782022Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival.12
355896862022The aspartyl protease DDI2 drives adaptation to proteasome inhibition in multiple myeloma.7
325212252020DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1.30
325212252020DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1.30
274610742016Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog.29
275281932016The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction.92
274610742016Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog.29
275281932016The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction.92
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

DDI2 (DNA damage inducible 1 homolog 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54251/ddi2-(dna-damage-inducible-1-homolog-2)