Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 84301
HGNC: 24578
Ensembl: ENSG00000197312
Variants:
dbSNP: 84301
ClinVar: 84301
TCGA: ENSG00000197312
COSMIC: DDI2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000197312 | ENST00000320153 | H0YII4 |
| ENSG00000197312 | ENST00000480945 | Q5TDH0 |
| ENSG00000197312 | ENST00000483899 | H0YI90 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37084817 | 2023 | UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage. | 1 |
| 37084817 | 2023 | UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage. | 1 |
| 34649278 | 2022 | Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival. | 12 |
| 35589686 | 2022 | The aspartyl protease DDI2 drives adaptation to proteasome inhibition in multiple myeloma. | 7 |
| 34649278 | 2022 | Multiple myeloma cells depend on the DDI2/NRF1-mediated proteasome stress response for survival. | 12 |
| 35589686 | 2022 | The aspartyl protease DDI2 drives adaptation to proteasome inhibition in multiple myeloma. | 7 |
| 32521225 | 2020 | DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1. | 30 |
| 32521225 | 2020 | DDI2 Is a Ubiquitin-Directed Endoprotease Responsible for Cleavage of Transcription Factor NRF1. | 30 |
| 27461074 | 2016 | Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog. | 29 |
| 27528193 | 2016 | The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction. | 92 |
| 27461074 | 2016 | Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog. | 29 |
| 27528193 | 2016 | The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction. | 92 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
Citation
Dessen P
DDI2 (DNA damage inducible 1 homolog 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-08-01
Online version: http://atlasgeneticsoncology.org/gene/54251/ddi2-(dna-damage-inducible-1-homolog-2)
